Nonpeptidic foldamers from amino acids: Synthesis and characterization of 1,3-substituted triazole oligomers

被引：191

作者：

Angelo, NG ^{[1
]}

Arora, PS ^{[1
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 49期

关键词：

D O I：

10.1021/ja056406z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nonpeptidic foldamers capable of displaying protein-like functionality were prepared by swapping amide bonds with 1,2,3-triazole rings. The overall conformation of these triazole oligomers is largely dictated by dipole-dipole interactions between adjacent rings. Solution NMR studies suggest that a zigzag conformation, which closely mimics the β-strand structure, predominates in two different tetramers. Copyright © 2005 American Chemical Society.

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页码：17134 / 17135

页数：2

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