An efficient synthesis of 3-aryl-2,3-dihydrothiophene-2-carboxamide derivatives by one-pot, four-component reaction

被引：3

作者：

Teng, Da ^{[1
]}

Xia, Sheng ^{[1
]}

Tao, Shimin ^{[1
]}

Gao, Lijiu ^{[1
]}

Feng, Youjian ^{[1
]}

Rong, Liangce ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Coll Chem & Chem Engn, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2013年 / 39卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Heterocycles; Cyclizations; Aldehydes; 2,3-Dihydrothiophene; Multicomponent reactions; SOLVENT-FREE CONDITIONS; STRUCTURE-BASED DESIGN; CHK1; INHIBITORS; MULTICOMPONENT REACTIONS; CHECKPOINT-1; BIOLOGICAL EVALUATION; 3-COMPONENT REACTION; 1,3-THIAZOLIDINEDIONE; KINASES;

D O I：

10.1007/s11164-012-0579-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and convenient method for the preparation of 3-aryl-2,3-dihydr-othiophene-2-carboxamide derivatives in absolute ethyl alcohol by thiazolidine-2,4-dione, aromatic aldehyde, malononitrile and n-butylamine without using any other catalysts was reported. This methodology has the advantages of high yields, simple work-up procedure and mild reaction conditions.

引用

页码：561 / 568

页数：8

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