An efficient synthesis of 3-aryl-2,3-dihydrothiophene-2-carboxamide derivatives by one-pot, four-component reaction

被引：3
作者：
Teng, Da [1 ]
Xia, Sheng [1 ]
Tao, Shimin [1 ]
Gao, Lijiu [1 ]
Feng, Youjian [1 ]
Rong, Liangce [1 ]
机构：
[1] Jiangsu Normal Univ, Coll Chem & Chem Engn, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2013年 / 39卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Heterocycles; Cyclizations; Aldehydes; 2,3-Dihydrothiophene; Multicomponent reactions; SOLVENT-FREE CONDITIONS; STRUCTURE-BASED DESIGN; CHK1; INHIBITORS; MULTICOMPONENT REACTIONS; CHECKPOINT-1; BIOLOGICAL EVALUATION; 3-COMPONENT REACTION; 1,3-THIAZOLIDINEDIONE; KINASES;
D O I：
10.1007/s11164-012-0579-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and convenient method for the preparation of 3-aryl-2,3-dihydr-othiophene-2-carboxamide derivatives in absolute ethyl alcohol by thiazolidine-2,4-dione, aromatic aldehyde, malononitrile and n-butylamine without using any other catalysts was reported. This methodology has the advantages of high yields, simple work-up procedure and mild reaction conditions.
引用
收藏
页码：561 / 568
页数：8
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