Pathogenesis of Food Allergy in the Pediatric Patient

被引：9

作者：

Chin, Stacy ^{[2
]}

Vickery, Brian P. ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Pediat, Div Pediat Allergy Immunol Rheumatol & Infect Dis, Chapel Hill, NC 27599 USA

[2] Duke Univ, Sch Med, Dept Pediat, Div Pediat Allergy & Immunol, Durham, NC USA

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2012年 / 12卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Food allergy; IgE; Allergic sensitization; Dendritic cells; Pathophysiology; Oral tolerance; Pathogenesis; Pediatric; INTESTINAL EPITHELIAL-CELLS; DENDRITIC CELLS; ORAL TOLERANCE; PEANUT ALLERGY; VITAMIN-D; MATERNAL AVOIDANCE; ATOPIC-DERMATITIS; IMMUNE-RESPONSES; RISK-FACTOR; CHILDREN;

D O I：

10.1007/s11882-012-0296-x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In the US and other developed countries, food allergy is a growing epidemic in pediatric populations with a substantial impact on health-related quality of life. As such, there are great efforts underway to unravel the mechanisms of oral mucosal tolerance and to better define the factors related to host and allergen exposure that contribute to the aberrant immune response leading to sensitization and clinical food allergy. Although more research is needed to eventually develop targeted treatment and prevention strategies, this review highlights our current understanding of the pathogenesis of IgE-mediated food allergy.

引用

页码：621 / 629

页数：9

共 97 条

[1] In vivo adjuvant-induced mobilization and maturation of gut dendritic cells after oral administration of cholera toxin [J].