Effect of Diet and Exercise, Alone or Combined, on Weight and Body Composition in Overweight-to-Obese Postmenopausal Women

被引:316
作者
Foster-Schubert, Karen E. [1 ,2 ]
Alfano, Catherine M. [3 ]
Duggan, Catherine R. [1 ]
Xiao, Liren [1 ]
Campbell, Kristin L. [4 ]
Kong, Angela [1 ]
Bain, Carolyn E. [1 ]
Wang, Ching-Yun [1 ,2 ]
Blackburn, George L. [5 ]
McTiernan, Anne [1 ,2 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
[2] Univ Washington, Sch Med, Seattle, WA USA
[3] NCI, Off Canc Survivorship, Bethesda, MD 20892 USA
[4] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada
[5] Harvard Univ, Sch Med, Boston, MA USA
关键词
LIFE-STYLE INTERVENTION; LONG-TERM; FAT; MASS; PREVENTION; PROGRAM; RESTRICTION; ADHERENCE; SUCCESS; ADULTS;
D O I
10.1038/oby.2011.76
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Lifestyle interventions for weight loss are the cornerstone of obesity therapy, yet their optimal design is debated. This is particularly true for postmenopausal women; a population with a high prevalence of obesity yet toward whom fewer studies are targeted. We conducted a year-long, 4-arm randomized trial among 439 overweight-to-obese postmenopausal sedentary women to determine the effects of a calorie-reduced, low-fat diet (D), a moderate-intensity, facility-based aerobic exercise program (E), or the combination of both interventions (D+E), vs. a no-lifestyle-change control (C) on change in body weight and composition. The group-based dietary intervention had a weight-reduction goal of >= 10%, and the exercise intervention consisted of a gradual escalation to 45-min aerobic exercise 5 day/week. Participants were predominantly non-Hispanic whites (85%) with a mean age of 58.0 +/- 5.0 years, a mean BMI of 30.9 +/- 4.0 kg/m(2) and an average of 47.8 +/- 4.4% body fat. Baseline and 12-month weight and adiposity measures were obtained by staff blinded to participants' intervention assignment. Three hundred and ninety nine women completed the trial (91% retention). Using an intention-to-treat analysis, average weight loss at 12 months was -8.5% for the D group (P < 0.0001 vs. C), -2.4% for the E group (P = 0.03 vs. C), and -10.8% for the D+E group (P < 0.0001 vs. C), whereas the C group experienced a nonsignificant -0.8% decrease. BMI, waist circumference, and % body fat were also similarly reduced. Among postmenopausal women, lifestyle-change involving diet, exercise, or both combined over 1 year improves body weight and adiposity, with the greatest change arising from the combined intervention.
引用
收藏
页码:1628 / 1638
页数:11
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