Improvement in psoriasis after treatment with the glucagon-like peptide-1 receptor agonist liraglutide

被引：47

作者：

Faurschou, A. ^{[1
]}

Knop, F. K. ^{[1
]}

Thyssen, J. P. ^{[2
]}

Zachariae, C. ^{[2
]}

Skov, L. ^{[2
]}

Vilsboll, T. ^{[1
]}

机构：

[1] Univ Copenhagen, Gentofte Hosp, Dept Internal Med F, Diabet Res Div, DK-2900 Hellerup, Denmark

[2] Univ Copenhagen, Gentofte Hosp, Dept Dermatoallergol, Copenhagen, Denmark

来源：

ACTA DIABETOLOGICA | 2014年 / 51卷 / 01期

关键词：

Glucagon-like peptide-1; Psoriasis; Type; 2; diabetes; Liraglutide; GASTRIC BYPASS-SURGERY; MYOCARDIAL-INFARCTION; RISK; EXPRESSION; REMISSION; OBESITY; GLP-1;

D O I：

10.1007/s00592-011-0359-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 59-year old man with moderate and stable psoriasis through 15 years was admitted to our Department with inadequately controlled type 2 diabetes. Treatment was initiated with the glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide. The patient experienced marked improvement in his psoriasis immediately after the start of liraglutide treatment. Itching stopped within days, scaling was reduced and spots of normal skin emerged. After 3 months, psoriasis was still improving. Excellent glycaemic control and a weight loss of approximately 8 kg over 3 months were moreover obtained. The patient had previously been well controlled in his diabetes without improvement in psoriasis, and the effect of liraglutide on psoriasis started before weight loss occurred. We discuss the possibility of a direct anti-inflammatory effect of liraglutide in psoriasis as well as indirect effects through improvement in comorbidities such as overweight. Randomized clinical trials are needed to reveal whether GLP-1R agonists represent a new therapeutic option for psoriasis.

引用

页码：147 / 150

页数：4

共 22 条

[1] Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study [J].

Ahlehoff, O. ;

Gislason, G. H. ;

Charlot, M. ;

Jorgensen, C. H. ;

Lindhardsen, J. ;

Olesen, J. B. ;

Abildstrom, S. Z. ;

Skov, L. ;

Torp-Pedersen, C. ;

Hansen, P. R. .

JOURNAL OF INTERNAL MEDICINE, 2011, 270 (02) :147-157

[2] Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study [J].

Astrup, Arne ;

Rossner, Stephan ;

Van Gaal, Luc ;

Rissanen, Aila ;

Niskanen, Leo ;

Al Hakim, Mazin ;

Madsen, Jesper ;

Rasmussen, Mads F. ;

Lean, Michael E. J. .

LANCET, 2009, 374 (9701) :1606-1616

[3] Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression [J].

Chung, Le Thi Kim ;

Hosaka, Toshio ;

Yoshida, Masaki ;

Harada, Nagakatsu ;

Sakaue, Hiroshi ;

Sakai, Tohru ;

Nakaya, Yutaka .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 390 (03) :613-618

[4] Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation [J].

Dozier, Kristopher C. ;

Cureton, Elizabeth L. ;

Kwan, Rita O. ;

Curran, Brian ;

Sadjadi, Javid ;

Victorino, Gregory P. .

PEPTIDES, 2009, 30 (09) :1735-1741

[5]

Ettinger JEMTM, 2006, OBES SURG, V16, P94

[6] Risk of myocardial infarction in patients with psoriasis [J].

Gelfand, Joel M. ;

Neimann, Andrea L. ;

Shin, Daniel B. ;

Wang, Xingmei ;

Margolis, David J. ;

Troxel, Andrea B. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 296 (14) :1735-1741

[7] Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells [J].

Hadjiyanni, I. ;

Siminovitch, K. A. ;

Danska, J. S. ;

Drucker, D. J. .

DIABETOLOGIA, 2010, 53 (04) :730-740

[8]

Hare KJ, 2010, VITAM HORM, V84, P389, DOI 10.1016/B978-0-12-381517-0.00015-1

[9] RETRACTED: A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells (Retracted article. See vol. 55, pg. 533, 2012) [J].

Hattori, Y. ;

Jojima, T. ;

Tomizawa, A. ;

Satoh, H. ;

Hattori, S. ;

Kasai, K. ;

Hayashi, T. .

DIABETOLOGIA, 2010, 53 (10) :2256-2263

[10] Psoriasis remission after laparoscopic Roux-en-Y gastric bypass for morbid obesity [J].

Higa-Sansone, G ;

Smomstein, S ;

Soto, M ;

Brasecsco, O ;

Cohen, C ;

Rosenthal, RJ .

OBESITY SURGERY, 2004, 14 (08) :1132-1134

← 1 2 3 →