Synthesis of 1,2-Dihydropyridines Catalyzed by Well-Defined Low-Valent Cobalt Complexes: C-H Activation Made Simple

被引：48
作者：
Fallon, Brendan J. [1 ]
Garsi, Jean-Baptiste [1 ]
Derat, Etienne [1 ]
Amatore, Muriel [1 ]
Aubert, Corinne [1 ]
Petit, Marc [1 ]
机构：
[1] Univ Paris 06, Sorbonne Univ, Inst Parisien Chim Mol, UMR CNRS 8232, F-75252 Paris 05, France
来源：
ACS CATALYSIS | 2015年 / 5卷 / 12期
关键词：
C-H activation; cobalt; 1,2-dihydropyridine; 6; pi-electrocylization; well-defined catalyst; mechanistic investigation; REGIOSELECTIVE CYCLOMETALATION; SUBSTITUTED PIPERIDINES; 2+2+2 CYCLOADDITION; BOND ACTIVATION; CARBON-HYDROGEN; ALKYNES; FUNCTIONALIZATION; IMINES; HYDROARYLATION; ALKENYLATION;
D O I：
10.1021/acscatal.5b02138
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A convenient one-pot system has been developed, allowing the synthesis of highly substituted dihydropyridines via a C-H activation/6 pi-electrocyclization pathway. The reaction proceeds with high regioselectivity, and we disclose the first example of isolated dihydropyridines lacking substitution in the 2 position. Moreover, the use of a simple well-defined low-valent cobalt complex without the need for reducing agents or additives in combination with computational studies provides a clearer insight into the C-H activation pathway than was previously reported.
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收藏
页码：7493 / 7497
页数：5
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