Immune Activation and the Role of TLRs and TLR Agonists in the Pathogenesis of HIV-1 Infection in the Humanized Mouse Model

被引：7
作者：
Chang, J. Judy
Altfeld, Marcus
机构：
[1] MIT, Massachusetts Inst Technol, Ragon Inst, Cambridge, MA 02139 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2013年 / 208卷
基金：
英国医学研究理事会;
关键词：
TLR; innate immunity; HIV-1; humanized mouse; pathogenesis; HUMAN-IMMUNODEFICIENCY-VIRUS; PLASMACYTOID DENDRITIC CELLS; SIV INFECTION; I INTERFERON; LYMPH-NODES; HIV-1-INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; NATURAL HOSTS; IFN-ALPHA; DC-SIGN;
D O I：
10.1093/infdis/jit402
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune activation plays a critical role in HIV-1 pathogenesis, but the pathways that are responsible for HIV-1-associated immune activation are not well understood. Recent advances in the development of a humanized mouse model for HIV-1 infection might provide new approaches to study the mechanisms of HIV-1 associated immune activation, and to test interventions aimed at reducing HIV-1 pathogenesis.
引用
收藏
页码：S145 / S149
页数：5
相关论文
共 50 条
  • [31] Dissecting drivers of immune activation in chronic HIV-1 infection
    Streeck, Hendrik
    Maestri, Alvino
    Habermann, Daniel
    Crowell, Trevor A.
    Esber, Allahna L.
    Son, Gowoon
    Eller, Leigh Anne
    Eller, Michael A.
    Parikh, Ajay P.
    Horn, Peter A.
    Maganga, Lucas
    Bahemana, Emmanuel
    Adamu, Yakubu
    Kiweewa, Francis
    Maswai, Jonah
    Owuoth, John
    Robb, Merlin L.
    Michael, Nelson L.
    Polyak, Christina S.
    Hoffmann, Daniel
    Ake, Julie A.
    [J]. EBIOMEDICINE, 2022, 83
  • [32] Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection
    Dubrovsky, Larisa
    Van Duyne, Rachel
    Senina, Svetlana
    Guendel, Irene
    Pushkarsky, Tatiana
    Sviridov, Dmitri
    Kashanchi, Fatah
    Bukrinsky, Michael
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 419 (01) : 95 - 98
  • [33] Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis
    MEISSNER Eric
    [J]. Science China(Life Sciences), 2010, (02) : 195 - 203
  • [34] Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis
    LiGuo Zhang
    Eric Meissner
    JianZhu Chen
    LiShan Su
    [J]. Science China Life Sciences, 2010, 53 : 195 - 203
  • [35] Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis
    Zhang LiGuo
    Meissner, Eric
    Chen JianZhu
    Su LiShan
    [J]. SCIENCE CHINA-LIFE SCIENCES, 2010, 53 (02) : 195 - 203
  • [36] MICE INFECTION WITH HIV-1 - A NEW MOUSE MODEL FOR HIV-1 INVIVO RESEARCH
    FILICE, G
    CEREDA, PM
    ORSOLINI, P
    SOLDINI, L
    GULMINETTI, R
    ROMERO, E
    [J]. MICROBIOLOGICA, 1992, 15 (02): : 167 - 175
  • [37] HIV-1 INFECTION OF ANIMALS - THE SEARCH FOR A PATHOGENESIS MODEL CONTINUES
    AGY, MB
    KATZE, MG
    [J]. AIDS, 1993, 7 : S37 - S42
  • [38] Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model
    Ikeda, Hiroki
    Nakaoka, Shinji
    de Boer, Rob J.
    Morita, Satoru
    Misawa, Naoko
    Koyanagi, Yoshio
    Aihara, Kazuyuki
    Sato, Kei
    Iwami, Shingo
    [J]. RETROVIROLOGY, 2016, 13
  • [39] Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model
    Hiroki Ikeda
    Shinji Nakaoka
    Rob J. de Boer
    Satoru Morita
    Naoko Misawa
    Yoshio Koyanagi
    Kazuyuki Aihara
    Kei Sato
    Shingo Iwami
    [J]. Retrovirology, 13
  • [40] Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression
    Hardy, Gareth A. D.
    Sieg, Scott F.
    Rodriguez, Benigno
    Jiang, Wei
    Asaad, Robert
    Lederman, Michael M.
    Harding, Clifford V.
    [J]. BLOOD, 2009, 113 (22) : 5497 - 5505
12345