Immune Activation and the Role of TLRs and TLR Agonists in the Pathogenesis of HIV-1 Infection in the Humanized Mouse Model

被引：7
|
作者：
Chang, J. Judy
Altfeld, Marcus
机构：
[1] MIT, Massachusetts Inst Technol, Ragon Inst, Cambridge, MA 02139 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2013年 / 208卷
基金：
英国医学研究理事会;
关键词：
TLR; innate immunity; HIV-1; humanized mouse; pathogenesis; HUMAN-IMMUNODEFICIENCY-VIRUS; PLASMACYTOID DENDRITIC CELLS; SIV INFECTION; I INTERFERON; LYMPH-NODES; HIV-1-INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; NATURAL HOSTS; IFN-ALPHA; DC-SIGN;
D O I：
10.1093/infdis/jit402
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune activation plays a critical role in HIV-1 pathogenesis, but the pathways that are responsible for HIV-1-associated immune activation are not well understood. Recent advances in the development of a humanized mouse model for HIV-1 infection might provide new approaches to study the mechanisms of HIV-1 associated immune activation, and to test interventions aimed at reducing HIV-1 pathogenesis.
引用
收藏
页码：S145 / S149
页数：5
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