RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy

被引：36

作者：

Xiang, Meiyi ^{[1
]}

Liu, Wensu ^{[1
]}

Tian, Wei ^{[1
]}

You, Abin ^{[1
]}

Deng, Dajun ^{[1
]}

机构：

[1] Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing,Div Etiol, Fu Cheng Lu 52, Beijing 100142, Peoples R China

来源：

EPIGENOMICS | 2020年 / 12卷 / 09期

关键词：

ALKBH5; cancer; drug resistance; FTO; m6A; METTL14; METTL3; RNA methylation; WTAP; METHYLTRANSFERASE METTL3 PROMOTES; M(6)A RNA; BREAST-CANCER; METHYLATION; GENE; EXPRESSION; DEMETHYLASE; PROTEIN; WTAP; RISK;

D O I：

10.2217/epi-2019-0358

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: As one of the early adaptive mechanisms by which cells respond to environmental changes, RNA modification appears to be a very promising target for cancer treatment. Results: RNA modifications are currently a hot topic in epigenetic research. Emerging experimental studies show that expression alterations of multiple m6A enzymes, including demethylase FTO, methyltransferase METTL3 and WTAP, mediate the development of resistance of cancer cells to various treatments. A set of small molecular chemical drugs targeted to these m6A enzymes are under development. Intervention of RNA m6A methylation is a possible therapeutic strategy to overcome drug resistance. Conclusions: RNA m6A methylation may play a crucial role in drug resistance development and intervention in cancer cells.

引用

页码：801 / 809

页数：9

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