Regional outcomes of severe acute respiratory syndrome coronavirus 2 infection in hospitalised patients with haematological malignancy

被引：22

作者：

Booth, Stephen ^{[1
]}

Willan, John ^{[1
,2
]}

Wong, Henna ^{[1
]}

Khan, Dalia ^{[1
]}

Farnell, Rachel ^{[1
]}

Hunter, Alicia ^{[3
]}

Eyre, Toby ^{[1
]}

Katz, Harley ^{[4
]}

Dungarwalla, Moez ^{[5
]}

Chen, Lucia ^{[5
]}

Browning, Joe ^{[6
]}

Polzella, Paolo ^{[6
]}

Gray, Nicola ^{[2
]}

Neelakantan, Pratap ^{[7
]}

Dhillon, Elissa K. ^{[7
]}

Dutton, David ^{[8
]}

Sternberg, Alex ^{[8
]}

Prideaux, Steven ^{[8
]}

Collins, Graham P. ^{[1
]}

Peniket, Andy ^{[1
]}

机构：

[1] Oxford Univ Hosp NHS Fdn Trust, Dept Haematol, Oxford, England

[2] Frimley Hlth NHS Fdn Trust, Dept Haematol, Frimley, England

[3] Univ Oxford, Radcliffe Dept Med Sch Clin Med, Oxford, England

[4] Univ Oxford, Astrophys Dept, Oxford, England

[5] Milton Keynes Univ Hosp NHS Fdn Trust, Dept Haematol, Milton Keynes, Bucks, England

[6] Buckinghamshire Healthcare NHS Trust, Dept Haematol, High Wycombe, Bucks, England

[7] Royal Berkshire Hosp NHS Fdn Trust, Dept Haematol, Reading, Berks, England

[8] Great Western Hosp NHS Fdn Trust, Dept Haematol, Swindon, Wilts, England

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2020年 / 105卷 / 04期

关键词：

haematological malignancy; SARS-CoV-2;

D O I：

10.1111/ejh.13469

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives We sought to characterise the outcomes of patients with haematological malignancy and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hospital in our regional network of 7 hospitals. Methods Consecutive hospitalised patients with haematological malignancy and SARS-CoV-2 infection were identified from 01/03/2020 to 06/05/2020. Outcomes were categorised as death, resolved or ongoing. The primary outcome was preliminary case fatality rate (pCFR), defined as the number of cases resulting in death as a proportion of all diagnosed cases. Analysis was primarily descriptive. Results 66 Patients were included, overall pCFR was 51.5%. Patients >= 70 years accounted for the majority of hospitalised cases (42, 63%) and fatalities (25, 74%). Mortality was similar between females (52%) and males (51%). Immunosuppressive or cytotoxic treatment within 3 months of the diagnosis of SARS-CoV-2 infection was associated with a significantly higher pCFR of 70%, compared with 28% in those not on active treatment (P = .0013, 2 proportionsztest). Conclusions Mortality rates in patients with haematological malignancy and SARS-CoV-2 infection in hospital are high supporting measures to minimise the risk of infection in this population.

引用

页码：476 / 483

页数：8

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