Serological comparison of antibodies to avian influenza viruses, subtypes H5N2, H6N1, H7N3 and H7N9 between poultry workers and non-poultry workers in Taiwan in 2012

被引：17

作者：

Huang, S. Y. ^{[1
]}

Yang, J. R. ^{[1
]}

Lin, Y. J. ^{[1
]}

Yang, C. H. ^{[1
]}

Cheng, M. C. ^{[2
]}

Liu, M. T. ^{[1
]}

Wu, H. S. ^{[1
,3
]}

Chang, F. Y. ^{[1
,4
]}

机构：

[1] Ctr Dis Control, Taipei 10050, Taiwan

[2] Anim Hlth Res Inst, Taipei, Taiwan

[3] Taipei Med Univ, Taipei, Taiwan

[4] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Div Infect Dis & Trop Med, Taipei, Taiwan

来源：

EPIDEMIOLOGY AND INFECTION | 2015年 / 143卷 / 14期

关键词：

Avian influenza virus; poultry worker; seroprevalence; HUMAN SERA; A VIRUS; INFECTION; HUMANS; ERYTHROCYTES;

D O I：

10.1017/S0950268815000394

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In Taiwan, avian influenza virus (AIV) subtypes H5N2, H6N1 and H7N3 have been identified in domestic poultry, and several strains of these subtypes have become endemic in poultry. To evaluate the potential of avian-to-human transmission due to occupational exposure, an exploratory analysis of AIV antibody status in poultry workers was conducted. We enrolled 670 poultry workers, including 335 live poultry vendors (LPVs), 335 poultry farmers (PFs), and 577 non-poultry workers (NPWs). Serum antibody titres against various subtypes of viruses were analysed and compared. The overall seropositivity rates in LPVs and PFs were 2.99% (10/335) and 1.79% (6/335), respectively, against H5N2; and 0.6% (2/335) and 1.19% (4/335), respectively, for H7N3 virus. Of NPWs, 0.35% (2/577) and 0.17% (1/577) were seropositive for H5N2 and H7N3, respectively. Geographical analysis revealed that poultry workers whose workplaces were near locations where H5N2 outbreaks in poultry have been reported face greater risks of being exposed to viruses that result in elevated H5N2 antibody titres. H6N1 antibodies were detected in only one PF, and no H7N9 antibodies were found in the study subjects. Subclinical infections caused by H5N2, H6N1 and H7N3 viruses were thus identified in poultry workers in Taiwan. Occupational exposure is associated with a high risk of AIV infection, and the seroprevalence of particular avian influenza strains in humans reflects the endemic strains in poultry in this region.

引用

页码：2965 / 2974

页数：10

共 33 条

[11] Evidence for avian influenza A infections among Iowa's agricultural workers [J].