Update on clinical trials for the prevention of acute kidney injury in patients undergoing cardiac surgery

被引：30

作者：

Alsabbagh, Mourad M. ^{[1
]}

Asmar, Abdo ^{[2
]}

Ejaz, Noel I. ^{[3
]}

Aiyer, Ravi K. ^{[1
]}

Kambhampati, Ganesh ^{[1
]}

Ejaz, A. Ahsan ^{[1
]}

机构：

[1] Univ Florida, Div Nephrol Hypertens & Renal Transplantat, Gainesville, FL 32610 USA

[2] Univ Cent Florida, Dept Clin Sci, Orlando, FL 32816 USA

[3] Univ Chicago, Chicago, IL 60637 USA

来源：

AMERICAN JOURNAL OF SURGERY | 2013年 / 206卷 / 01期

关键词：

Acute kidney injury; Clinical trials; Cardiac surgery; Diagnosis; Prevention; Treatment; ACUTE-RENAL-FAILURE; INTRAAORTIC BALLOON PUMP; HIGH-RISK PATIENTS; LEFT-VENTRICULAR DYSFUNCTION; ARTERY-BYPASS SURGERY; ALL-CAUSE MORTALITY; CARDIOPULMONARY-BYPASS; OFF-PUMP; SURGICAL-PATIENTS; DOUBLE-BLIND;

D O I：

10.1016/j.amjsurg.2012.08.007

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BACKGROUND: Effective therapeutic agents for the prevention and treatment of acute kidney injury (AKI) after cardiac surgery remain elusive despite the tremendous advances in surgical techniques, technology, and understanding of disease processes. Recent developments and their effect on the incidence of AKI after cardiac surgery are discussed. DATA SOURCES: Published clinical trials in PubMed, strength of evidence assessed by the guidelines of the American Family Physicians. CONCLUSIONS: The definition of AKI has changed, and the focus of interventions has shifted from treatment to prevention to recovery from AKI. Antioxidants and biological agents have been added to classic armaments of hydration and diuretics in addition to tighter metabolic control to prevent AKI. Although the treatment options remain unsatisfactory, a lot of progress nevertheless continues to be made in the prevention and treatment of AKI. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：86 / 95

页数：10

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