Oncogene signal transduction inhibitors from Chinese medicinal plants

被引：9

作者：

Chang, CJ ^{[1
]}

Ashendel, CL ^{[1
]}

Chan, TCK ^{[1
]}

Geahlen, RL ^{[1
]}

McLaughlin, J ^{[1
]}

Waters, DJ ^{[1
]}

机构：

[1] Purdue Univ, Dept Med Chem & Mol Pharmacol, Dept Vet Pharmacol & Physiol, Dept Vet Clin Sci, W Lafayette, IN 47907 USA

来源：

PURE AND APPLIED CHEMISTRY | 1999年 / 71卷 / 06期

关键词：

D O I：

10.1351/pac199971061101

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oncogene modulated signal transduction based on intracellular phosphorylation of protein tyrosine or serine/threonine has been utilized as a target for oncogene-based anti-cancer drug discovery. Inhibition of protein-tyrosine kinase and protein kinase C directed prescreen has identified numerous potential anti-tumor Chinese medicinal plants. Further bioassay guided fractionation and separation have led to the discovery of novel protein kinase inhibitors, anthraquinones, stilbenes and polythiophenes as potential anti-tumor agents.

引用

页码：1101 / 1104

页数：4

共 21 条

[1] THE POTENTIAL OF PROTEIN-KINASE-C AS A TARGET FOR ANTICANCER TREATMENT [J].