Calorie restriction and sirtuins revisited

被引：351

作者：

Guarente, Leonard ^{[1
]}

机构：

[1] MIT, Dept Biol, Glenn Lab Sci Aging, Cambridge, MA 02139 USA

来源：

GENES & DEVELOPMENT | 2013年 / 27卷 / 19期

关键词：

CR mimetics; calorie restriction; sirtuins; NF-KAPPA-B; FATTY-ACID OXIDATION; LIFE-SPAN EXTENSION; ACTIVATED PROTEIN-KINASE; PANCREATIC BETA-CELLS; STIMULATED INSULIN-SECRETION; HISTONE DEACETYLASE SIRT6; DEPENDENT GENE-EXPRESSION; SMALL-MOLECULE ACTIVATORS; INDUCIBLE FACTOR 1-ALPHA;

D O I：

10.1101/gad.227439.113

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years. This review addresses these challenges and draws from a great body of new data in the sirtuin field that shows a systematic redirection of mammalian physiology in response to diet by sirtuins. The prospects for drugs that can deliver at least a subset of the benefits of CR seems very real.

引用

页码：2072 / 2085

页数：14

共 194 条

[1] Motif module map reveals enforcement of aging by continual NF-κB activity [J].

Adler, Adam S. ;

Sinha, Saurabh ;

Kawahara, Tiara L. A. ;

Zhang, Jennifer Y. ;

Segal, Eran ;

Chang, Howard Y. .

GENES & DEVELOPMENT, 2007, 21 (24) :3244-3257

[2] Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)" [J].

Albani, Diego ;

Ateri, Eleonora ;

Mazzuco, Stefano ;

Ghilardi, Alice ;

Rodilossi, Serena ;

Biella, Gloria ;

Ongaro, Fausta ;

Antuono, Piero ;

Boldrini, Paolo ;

Di Giorgi, Enrico ;

Frigato, Andrea ;

Durante, Elisabetta ;

Caberlotto, Livio ;

Zanardo, Andrea ;

Siculi, Marinella ;

Gallucci, Maurizio ;

Forloni, Gianluigi .

AGE, 2014, 36 (01) :469-478

[3] Sirt1 regulates aging and resistance to oxidative stress in the heart [J].

Alcendor, Ralph R. ;

Gao, Shumin ;

Zhai, Peiyong ;

Zablocki, Daniela ;

Holle, Eric ;

Yu, Xianzhong ;

Tian, Bin ;

Wagner, Thomas ;

Vatner, Stephen F. ;

Sadoshima, Junichi .

CIRCULATION RESEARCH, 2007, 100 (10) :1512-1521

[4] Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae [J].

Anderson, RM ;

Bitterman, KJ ;

Wood, JG ;

Medvedik, O ;

Sinclair, DA .

NATURE, 2003, 423 (6936) :181-185

[5] SIRT1 regulates circadian clock gene expression through PER2 deacetylation [J].

Asher, Gad ;

Gatfield, David ;

Stratmann, Markus ;

Reinke, Hans ;

Dibner, Charna ;

Kreppel, Florian ;

Mostoslavsky, Raul ;

Alt, Frederick W. ;

Schibler, Ueli .

CELL, 2008, 134 (02) :317-328

[6] dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner [J].

Banerjee, Kushal Kr. ;

Ayyub, Champakali ;

Ali, Syed Zeeshan ;

Mandot, Vinesh ;

Prasad, Nagaraj G. ;

Kolthur-Seetharam, Ullas .

CELL REPORTS, 2012, 2 (06) :1485-1491

[7] SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice [J].

Banks, Alexander S. ;

Kon, Ning ;

Knight, Colette ;

Matsumoto, Michihiro ;

Gutierrez-Juarez, Roger ;

Rossetti, Luciano ;

Gu, Wei ;

Accili, Domenico .

CELL METABOLISM, 2008, 8 (04) :333-341

[8] A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice [J].

Barger, Jamie L. ;

Kayo, Tsuyoshi ;

Vann, James M. ;

Arias, Edward B. ;

Wang, Jelai ;

Hacker, Timothy A. ;

Wang, Ying ;

Raederstorff, Daniel ;

Morrow, Jason D. ;

Leeuwenburgh, Christiaan ;

Allison, David B. ;

Saupe, Kurt W. ;

Cartee, Gregory D. ;

Weindruch, Richard ;

Prolla, Tomas A. .

PLOS ONE, 2008, 3 (06)

[9]

Bauer JH, 2009, AGING-US, V1, P38

[10] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

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