Facile Synthesis and Biological Evaluation of Substituted 5-(1H-Indol-3-ylmethylene) pyrimidine-2,4,6-trione Derivatives Using L-Tyrosine in Aqueous Medium

被引：1

作者：

Thirupathi, G. ^{[1
]}

Dubey, P. K. ^{[1
]}

Kumari, Y. Bharathi ^{[1
]}

机构：

[1] Jawaharlal Nehru Technol Univ Hyderabad, Coll Engn, Dept Chem, Hyderabad 500085, Andhra Pradesh, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 15期

关键词：

Antibacterial activities; Antifungal activities; Indole-3-aldehyde; Barbituric acid; L-Tyrosine; Knoevenagel reaction; ONE-POT SYNTHESIS; KNOEVENAGEL CONDENSATION; ZINC-CHLORIDE; IONIC LIQUIDS; MELDRUMS ACID; INHIBITORS; CATALYST;

D O I：

10.14233/ajchem.2013.15364

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

L-Tyrosine as an efficient catalyst for the Knoevenagel condensation of substituted indole-3-aldehydes 1(a-d), N-methyl indole-3-aldehydes 4(a-d), N-ethyl indole-3-aldehydes 6(a-d) with barbituric acid (2) containing cyclic active methylene group to produce 3(a-d), 5(a-d) and 7(a-d), respectively in water at room temperature for 10 min. The antimicrobial activities of 3(a-d), 5(a-d) and 7(a-d) have been studied.

引用

页码：8741 / 8748

页数：8

共 38 条

[1]

[Anonymous], 1991, Comprehensive Organic Synthesis

[2]

[Anonymous], KNOEVENAGEL REACT

[3] KNOEVENAGEL CONDENSATION IN THE HETEROGENEOUS PHASE USING ALPO4-AL2O3 AS A NEW CATALYST [J].