Alpha Lipoamide Ameliorates Motor Deficits and Mitochondrial Dynamics in the Parkinson's Disease Model Induced by 6-Hydroxydopamine

被引:19
作者
Zhou, Bo [1 ,2 ,3 ]
Wen, Min [3 ]
Lin, Xin [3 ]
Chen, Yun-Hua [3 ]
Gou, Yun [3 ]
Li, Yong [1 ,2 ,4 ]
Zhang, Yi [1 ,2 ,4 ]
Li, Hong-Wei [3 ]
Tang, Lei [1 ,2 ,4 ]
机构
[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550004, Guizhou, Peoples R China
[2] Engn Technol Res Ctr Chem Drug R&D, Guiyang 550004, Guizhou, Peoples R China
[3] Guizhou Med Univ, Coll Basic Med, Guiyang 550004, Guizhou, Peoples R China
[4] Guizhou Med Univ, Coll Pharm, Guiyang 550004, Guizhou, Peoples R China
关键词
Parkinson's disease; 6-Hydroxydopamine; Alpha lipoamide; Mitochondrial dynamics; LIPOIC ACID PROTECTS; DOPAMINERGIC-NEURONS; AXONAL-TRANSPORT; FISSION; FUSION; NEUROTOXICITY; DYSFUNCTION;
D O I
10.1007/s12640-017-9819-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The precise mechanisms underlying neuronal injury in Parkinson's disease (PD) are not yet fully elucidated; however, evidence from the in vitro and in vivo PD models suggest that mitochondrial dysfunction may play a major role in PD pathogenesis. Alpha lipoamide, a neutral amide derivative of the lipoic acid, is a better cofactor for mitochondrial dehydrogenase with a stronger protective effect on mitochondria than lipoic acid. Identification of these protective effects of alpha lipoamide on mitochondria, together with the evidence that mitochondrial dysfunction plays a critical role in PD, we speculate that alpha lipoamide may exert a protective effect in PD by regulating the mitochondrial function. The present study investigated the neuroprotective effects of alpha lipoamide in an animal model of PD induced by 6-hydroxydopamine (6-OHDA). The results demonstrated that alpha lipoamide could significantly antagonize the 6-OHDA-induced behavioral damages; restore ATP levels in the midbrain; and also improve the fragmentation, vacuolization, and morphology of the mitochondria. The results of Western blot indicated that alpha lipoamide significantly restored the number of dopaminergic neurons in midbrain and substantially recovered the balance between mitochondrial fission, fusion, and transport. In conclusion, the results demonstrated that alpha lipoamide might exert a significant neuroprotective effect in the animal model of PD by regulation of the dynamic properties of mitochondria.
引用
收藏
页码:759 / 767
页数:9
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