Continuous-Flow Synthesis of Phenothiazine Antipsychotics: A Feasibility Study

被引：4
|
作者：
Movsisyan, Marine [1 ]
De Coen, Laurens M. [1 ]
Heugebaert, Thomas S. A. [1 ]
Verlee, Arno [1 ]
Roman, Bart I. [1 ]
Stevens, Christian V. [1 ]
机构：
[1] Bioresources & Bioorgan Chem Res Grp, Dept Green Chem & Technol Synth, Coupure Links 653, Ghent, Belgium
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 06期
关键词：
Continuous flow; Microreactors; Synthetic methods; Phenothiazine; Heterocycles; ORGANIC-SYNTHESIS; DRUG-DISCOVERY; CHEMISTRY; TOOLS;
D O I：
10.1002/ejoc.201801689
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.
引用
收藏
页码：1350 / 1354
页数：5
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