Continuous-Flow Synthesis of Phenothiazine Antipsychotics: A Feasibility Study

被引:4
|
作者
Movsisyan, Marine [1 ]
De Coen, Laurens M. [1 ]
Heugebaert, Thomas S. A. [1 ]
Verlee, Arno [1 ]
Roman, Bart I. [1 ]
Stevens, Christian V. [1 ]
机构
[1] Bioresources & Bioorgan Chem Res Grp, Dept Green Chem & Technol Synth, Coupure Links 653, Ghent, Belgium
关键词
Continuous flow; Microreactors; Synthetic methods; Phenothiazine; Heterocycles; ORGANIC-SYNTHESIS; DRUG-DISCOVERY; CHEMISTRY; TOOLS;
D O I
10.1002/ejoc.201801689
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.
引用
收藏
页码:1350 / 1354
页数:5
相关论文
共 50 条
  • [21] Continuous-flow Synthesis of Anisotropic Plasmonic Nanostructures
    Singh, Vini
    Sridhar, Perali Ramu
    Singh, R.
    JOURNAL OF FLOW CHEMISTRY, 2024, 14 (02) : 397 - 407
  • [22] Two step continuous-flow synthesis of benzocaine
    Franca, Alexandre de S.
    Leao, Raquel A. C.
    de Souza, Rodrigo O. M. A.
    JOURNAL OF FLOW CHEMISTRY, 2020, 10 (03) : 563 - 569
  • [23] Continuous-Flow Synthesis of (-)-Oseltamivir Phosphate (Tamiflu)
    Sagandira, Cloudius R.
    Watts, Paul
    SYNLETT, 2020, 31 (19) : 1925 - 1929
  • [24] Efficient Continuous-Flow Synthesis of Macrocyclic Triazoles
    Bedard, Anne-Catherine
    Santandrea, Jeffrey
    Collins, Shawn K.
    JOURNAL OF FLOW CHEMISTRY, 2015, 5 (03) : 142 - 144
  • [25] High Yielding Continuous-Flow Synthesis of Norketamine
    Hernando, Marcos Veguillas
    Moore, Jonathan C.
    Howie, Rowena A.
    Castledine, Richard A.
    Bourne, Samuel L.
    Jenkins, Gareth N.
    Licence, Peter
    Poliakoff, Martyn
    George, Michael W.
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2022, 26 (04) : 1145 - 1151
  • [26] Multistep Continuous-Flow Synthesis of Condensed Benzothiazoles
    Klára Lövei
    István Greiner
    János Éles
    Áron Szigetvári
    Miklós Dékány
    Sándor Lévai
    Zoltán Novák
    György István Túrós
    Journal of Flow Chemistry, 2015, 5 : 74 - 81
  • [27] Synthesis of Bicyclic Esters in a Continuous-Flow Microreactor
    Feng Bai-cheng
    Hou Xi-chao
    Wang Tie-lin
    Lu Jian-qiang
    Jin Yan
    CHEMISTRYSELECT, 2020, 5 (03): : 952 - 956
  • [28] Influence of laminar flow on dispersity in continuous-flow polymer synthesis
    Leibfarth, Frank
    Reis, Marcus
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [29] Non-aqueous continuous-flow electrophoresis (NACFE): potential separation complement for continuous-flow organic synthesis
    Ivanov, Nikita A.
    Liu, Yimo
    Kochmann, Sven
    Krylov, Sergey N.
    LAB ON A CHIP, 2019, 19 (13) : 2156 - 2160
  • [30] CONTINUOUS-FLOW RADIOIMMUNOASSAY - COMPLETELY AUTOMATED CONTINUOUS-FLOW RADIOIMMUNOASSAY SYSTEM
    ANDERSON, MJ
    MEDICAL LABORATORY SCIENCES, 1978, 35 (02): : 173 - 185