Ibuprofen treatment versus gradual introduction of interferon β-1b in patients with MS

被引：25

作者：

Rice, GPA

Ebers, GC

Lublin, FD

Knobler, RL

机构：

[1] London Hlth Sci Ctr, London, ON N6A 5A5, Canada

[2] Med Coll Penn & Hahnemann Univ, Philadelphia, PA USA

[3] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA

来源：

NEUROLOGY | 1999年 / 52卷 / 09期

关键词：

D O I：

10.1212/WNL.52.9.1893

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Flu-like symptoms and injection site reactions are adverse effects of treatment with interferon beta-1b in patients with MS. We compared gradual dose escalation, ibuprofen treatment, or their combination in an open-label study. The combination reduced the incidence of flu-like symptoms to rates comparable with the placebo group in the pivotal trial but increased the frequency of injection site reactions, albeit modestly and transiently.

引用

页码：1893 / 1895

页数：3

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