Type I interferon induces CX3CL1 (fractalkine) and CCL5 (RANTES) production in human pulmonary vascular endothelial cells

被引：54

作者：

Nakano, M. ^{[2
,3
]}

Fujii, T. ^{[1
,2
]}

Hashimoto, M.

Yukawa, N. ^{[2
]}

Yoshifuji, H. ^{[2
]}

Ohmura, K. ^{[2
]}

Nakaizumi, A. ^{[3
]}

Mimori, T. ^{[2
]}

机构：

[1] Kyoto Univ, Dept Control Rheumat Dis, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan

[2] Kyoto Univ, Dept Rheumatol & Clin Immunol, Grad Sch Med, Kyoto 6068507, Japan

[3] Kyoto Univ, Dept Appl Lab Sci, Grad Sch Med, Kyoto 6068507, Japan

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2012年 / 170卷 / 01期

关键词：

CCL5 (RANTES); connective tissue disease; CX3CL1 (fractalkine); pulmonary vascular disease; type I interferon; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ARTERIAL-HYPERTENSION; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; CHEMOKINE; EXPRESSION; RECEPTOR; BETA; MANIFESTATIONS; ACTIVATION;

D O I：

10.1111/j.1365-2249.2012.04638.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I interferon (IFN) medications cause various adverse reactions, including vascular diseases. Although an association between chemokines and vascular diseases has also been reported, the relationship between type I IFN and chemokines in vascular endothelial cells (VEC) remains unclear. To provide clues to pathogenesis of the diseases, we analysed the effects of type I IFN on chemokine production in human VEC. Type I IFN induced higher CX3CL1 (fractalkine) mRNA expression and protein secretion in pulmonary arterial VEC than in umbilical vein VEC. Type I IFN also induced CCL5 [regulated upon activation normal T cell expressed and secreted (RANTES)] production in VEC, especially in lung micro-VEC. IFN-beta induced much higher chemokine production than IFN-a, and Janus protein tyrosine kinase (JAK) inhibitor I prevented type I IFN-induced chemokine secretion. Type I IFN-induced chemokines may be involved in the pathophysiology of pulmonary vascular diseases, and the JAK inhibitor may serve as a therapeutic option for these diseases.

引用

页码：94 / 100

页数：7

共 40 条

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