Elevated third-trimester haemoglobin A1c predicts preterm delivery in type 1 diabetes

被引:39
作者
Ekbom, Pia [1 ]
Damm, Peter [2 ]
Feldt-Rasmussen, Bo [3 ]
Feldt-Rasmussen, Ulla [1 ]
Jensen, Dorte M. [4 ]
Mathiesen, Elisabeth R. [1 ]
机构
[1] Rigshosp, Natl Univ Hosp, Endocrine Clin, DK-2100 Copenhagen, Denmark
[2] Natl Univ Hosp, Copenhagen & Steno Diabet Ctr, Obstet Clin, Gentofte, Denmark
[3] Natl Univ Hosp, Nephrol Clin, Copenhagen, Denmark
[4] Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense, Denmark
关键词
premature labour; glycated haemoglobin; insulin-dependent diabetes mellitus; pregnancy in diabetes; Caucasian race;
D O I
10.1016/j.jdiacomp.2007.03.008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The prevalence of preterm delivery is considerably elevated in women with type 1 diabetes. The aim of the study was to evaluate haemoglobin A(1c) (HbA(1c)) as a predictor of preterm delivery. Two hundred thirteen consecutive pregnant women with type 1 diabetes and normal urinary albumin excretion were included prospectively. HbA(1c) was analyzed at 10, 20 and 28 weeks of gestation. Seventy-one women (33%) delivered pre term and 142 at term. At 10 weeks of gestation, HbA(1c) was 7.3% (S.D. 1.0) vs. 6.9% (S.D. 0.9) (P<.01), at 20 weeks of gestation 6.6% (S.D. 0.7) vs. 6.1% (S.D. 0.7) (P<.001) and at 28 weeks of gestation 6.7% (S.D. 0.8) vs. 6.1% (S.D. 0.7) (P<.001). When comparing HbA(1c) at 10, 20 and 28 weeks of gestation, HbA(1c) at 28 weeks of gestation (P<.001) was the best predictor of preterm delivery. The adjusted odds ratio per 1% increment in HbA(1c) at 28 weeks of gestation was 2.8 (95% CI 1.7-4.4). HbA(1c) at 28 weeks of gestation was a clinical significant predictor of preterm delivery in type 1 diabetes. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:297 / 302
页数:6
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