Mucinous borderline tumours of the ovary and the appendix: A retrospective study and overview of the literature

被引:39
作者
Kleppe, M. [1 ]
Bruls, J. [2 ]
Van Gorp, T. [1 ,3 ]
Massuger, L. [2 ]
Slangen, B. F. M. [1 ,3 ]
Van de Vijver, K. K. [3 ,4 ]
Kruse, A. J. [1 ,3 ]
Kruitvvagen, R. F. P. M. [1 ,3 ]
机构
[1] Maastricht Univ, Med Ctr, Dept Obstet & Gynecol, NL-6202 AZ Maastricht, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Obstet & Gynecol, NL-6525 ED Nijmegen, Netherlands
[3] GROW Sch Oncol & Dev Biol, Maastricht, Netherlands
[4] Maastricht Univ, Med Ctr, Dept Pathol, NL-6202 AZ Maastricht, Netherlands
关键词
Borderline tumour of the ovary; Appendix; PSEUDOMYXOMA-PERITONEI; CLINICOPATHOLOGICAL ANALYSIS; PATHOLOGY; ORIGIN; MANAGEMENT; PROGNOSIS; EMPHASIS; TIME; SITE;
D O I
10.1016/j.ygyno.2014.02.013
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives. Appendectomy is often recommended in patients with mucinous borderline ovarian tumours (mBOTs) based on studies suggesting that metastatic disease from a primary appendiceal tumour can mimic mBOT. The present study assessed the incidence of mucinous neoplasms in the appendix associated with the presence of mBOT. Methods. A retrospective cohort study was performed in two university hospitals in the Netherlands between 1990 and 2011. All patients with mBOT and/or a mucinous appendiceal tumour were included. Results. Of 127 patients included, 98 had a primary mBOT and 29 had a primary mucinous appendiceal tumour. In patients with a mBOT, the appendix was either removed at prior surgery (4%), resected as part of the staging procedure showing no pathological abnormalities (13%), described as normal and not resected (58%), or not described and not resected (25%). During a median follow-up period of 5 years (range 2-23), two patients developed a recurrence in which the appendix was not involved. In all patients with a primary mucinous tumour of the appendix, the appendix appeared abnormal at the time of surgery. Eight of these patients (28%) were diagnosed with invasive ovarian metastases. A review of the literature including the cases from this study identified 510 mucinous ovarian tumours with borderline features and 214 associated appendectomies, of which 4 (1.9%) contained a primary appendiceal malignancy. Conclusions. A thorough inspection of the appendix should be performed in patients with a mucinous ovarian tumour with borderline features. An appendectomy should only be performed when the appendix is macroscopically abnormal. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:155 / 158
页数:4
相关论文
共 26 条
[1]   Management of borderline ovarian neoplasms [J].
Cadron, Isabelle ;
Leunen, Karin ;
Van Gorp, Toon ;
Amant, Frederic ;
Neven, Patrick ;
Vergote, Ignace .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (20) :2928-2937
[2]   The management of borderline tumours of the ovary [J].
Cadron, Isabelle ;
Amant, Frederic ;
Van Gorp, Toon ;
Neven, Patrick ;
Leunen, Karin ;
Vergote, Ignace .
CURRENT OPINION IN ONCOLOGY, 2006, 18 (05) :488-493
[3]   Impact of surgical staging in patients with macroscopic "stage I" ovarian borderline tumours: analysis of a continuous series of 101 cases [J].
Camatte, S ;
Morice, P ;
Thoury, A ;
Fourchotte, V ;
Pautier, P ;
Lhomme, C ;
Duvillard, P ;
Castaigne, D .
EUROPEAN JOURNAL OF CANCER, 2004, 40 (12) :1842-1849
[4]  
Casparie M, 2007, CELL ONCOL, V29, P19
[5]   Genetic analysis of synchronous mucinous tumors of the ovary and appendix [J].
Chuaqui, RF ;
Zhuang, ZP ;
Emmertbuck, MR ;
Bryant, BR ;
Nogales, F ;
Tavassoli, FA ;
Merino, MJ .
HUMAN PATHOLOGY, 1996, 27 (02) :165-171
[6]   Synchronous mucinous tumors of the appendix and the ovary associated with pseudomyxoma peritonei - A clinicopathologic study of six cases with comparative analysis of c-Ki-ras mutations [J].
Cuatrecasas, M ;
MatiasGuiu, X ;
Prat, J .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (06) :739-746
[7]   Is Routine Appendectomy at the Time of Primary Surgery for Mucinous Ovarian Neoplasms Beneficial? [J].
Feigenberg, Tomer ;
Covens, Allan ;
Ghorab, Zeina ;
Ismiil, Nadia ;
Dube, Valerie ;
Saad, Reda S. ;
Khalifa, Mahmoud A. ;
Nofech-Mozes, Sharon .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2013, 23 (07) :1205-1209
[8]   The clinical land economic correlates of misdiagnosed appendicitis - Nationwide analysis [J].
Flum, DR ;
Koepsell, T .
ARCHIVES OF SURGERY, 2002, 137 (07) :799-804
[9]   Systematic Evaluation of the Intraoperative Tumor Pattern in Patients With Borderline Tumor of the Ovary [J].
Fotopoulou, Christina ;
Schumacher, Guido ;
Schefold, Joerg C. ;
Denkert, Carsten ;
Lichtenegger, Werner ;
Sehouli, Jalid .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2009, 19 (09) :1550-1555
[10]  
GUERRIERI C, 1995, MODERN PATHOL, V8, P573