Echocardiographic assessment of myocardial function in workers occupationally exposed to lead without clinically evident heart disease

被引：5

作者：

Poreba, Rafal ^{[1
]}

Gac, Pawel ^{[1
]}

Poreba, Malgorzata ^{[2
]}

Mazur, Grzegorz ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Internal Med Occupat Dis & Hypertens, PL-50556 Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Pathophysiol, PL-50368 Wroclaw, Poland

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2013年 / 36卷 / 02期

关键词：

Occupational exposure; Echocardiography; Lead; Heart; BETA-ADRENERGIC SYSTEM; SMOOTH-MUSCLE-CELLS; BLOOD-PRESSURE; HYPERTENSION;

D O I：

10.1016/j.etap.2013.05.010

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Purpose: The aim of the study was to evaluate echocardiographic changes in workers occupationally exposed to low doses of lead. Methods: We enrolled 63 men occupationally exposed to lead into the study (group I). Unexposed group consisted of 49 healthy men (group II). Blood lead concentration (Pb-B) and blood zinc protoporphyrin concentration (ZnPP) were determined. Transthoracic echocardiographic examination was performed. Results: In the studied groups, selected on the criterion of occupational exposure to lead, comparative analysis of echocardiographic parameters indicated statistically significant differences. A negative linear correlations between ZnPP and E' was observed in group I. It was proved that a higher concentration of ZnPP is independent risk factor of lowering the E' mean value in group I. Conclusions: Occupational exposure to low doses of lead is associated with the occurrence of discreet morphological and functional heart changes that in the future may predispose to disclosed pathology of heart. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：522 / 528

页数：7

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