Metabolites with cytotoxic activity from the Formosan soft coral Cladiella australis

被引：19

作者：

Ahmed, AF

Wu, MH

Wu, YC

Dai, CF

Sheu, JH ^{[1
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Univ Mansoura, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

[3] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[4] Natl Taiwan Univ, Inst Oceanog, Taipei 106, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2006年 / 53卷 / 02期

关键词：

Cladiella australis; steroids; 5 '-O-acetylthymidine; 3 '-O-acetylthymidine; p-vinylbenzyl alcohol; cytotoxicity; soft coral;

D O I：

10.1002/jccs.200600064

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The metabolites, (24S)-3 beta-acetoxyergost-5-en-21-oic acid (2), 5'-O-acetylthymidine (3), 3'-O-acetylthymidine (4), and p-vinylbenzy] alcohol (5), along with a known steroid (1) were isolated from the EtOAc extract of the Formosan soft coral Caldiella australis. The structures of new metabolites were determined on the basis of spectroscopic (including 1D and 2D NMR) analyses and by comparison of their NMR spectral data with those of related compounds. Except for 3, all compounds exhibited cytotoxic activity of various degrees of potency against a limited panel of human liver and breast cancer cell lines.

引用

页码：489 / 494

页数：6

共 15 条

[1] CHLOROMETHYLATION OF BETA-CHLOROETHYLBENZENE AND PREPARATION OF P-VINYLBENZYL ALCOHOL [J].