Accuracy of transcutaneous bilirubin measurement in preterm low-birth-weight neonates

被引:24
作者
Chawla, Deepak [1 ]
Jain, Suksham [1 ]
Kaur, Gurjit [2 ]
Sinhmar, Vikas [2 ]
Guglani, Vishal [1 ]
机构
[1] Govt Med Coll Hosp, Dept Pediat, Chandigarh 160030, India
[2] Govt Med Coll Hosp, Dept Physiol, Chandigarh 160030, India
关键词
Preterminfants; Hyperbilirubinemia; Screening; Transcutaneous bilirubin; JAUNDICE; INFANTS; CAPILLARY; SERUM;
D O I
10.1007/s00431-013-2142-0
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The objective of this study was to evaluate the correlation and agreement between transcutaneous and serum bilirubin among preterm low-birth-weight neonates. Neonates born at < 35 weeks of gestation with birth weight < 2,000 g were enrolled prospectively. Transcutaneous bilirubin (TcB) was measured at forehead, sternum, and abdomen at 24 +/- 6 and 72 +/- 12 h after birth and when icterus involved arms or legs (Kramer zone 4-5). Serum total bilirubin (STB) was measured by microbilimeter (STB-M) at all these time-points and by high-performance liquid chromatography (STB-H) at one randomly chosen time-point. A total of 1,619 observations were made in 256 neonates (median gestation, 34 weeks (IQR, 32-35), birth weight 1,522 +/- 288 g). Overall there was excellent correlation and agreement between TcB and STB-M with TcB on forehead being most accurate (r = 0.84, mean difference, 0.3 +/- 1.9 mg/dL) followed by TcB on abdomen (r = 0.73, mean difference, 1.5 +/- 2.6 mg/dL) and sternum (r = 0.72, mean difference, 1.5 +/- 2.6 mg/dL). TcB performed well at all three points of measurement with best correlations being observed at icterus level 4/5. Correlation between TcB and STB-H measured by high-performance liquid chromatography was less strong but significant (r = 0.59 to 0.69 at different time points of measurement). Conclusions: TcB has good correlation and agreement with STB in preterm low-birth-weight neonates born at a parts per thousand yen28 weeks of gestation.
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页码:173 / 179
页数:7
相关论文
共 33 条
  • [31] Vreman HJ, 1996, CLIN CHEM, V42, P869
  • [32] Willems W A, 2004, J Matern Fetal Neonatal Med, V16, P209
  • [33] ZHANG JX, 1992, SCAND J CLIN LAB INV, V52, P565