Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 for Patients With Metabolic Syndrome Is the Target Liver, Fat, or Both?

被引：24

作者：

Stewart, Paul M. ^{[1
]}

Tomlinson, Jeremy W.

机构：

[1] Univ Birmingham, Dept Endocrinol, Birmingham, W Midlands, England

来源：

DIABETES | 2009年 / 58卷 / 01期

关键词：

SPLANCHNIC CORTISOL PRODUCTION; ADIPOSE-TISSUE; INSULIN SENSITIVITY; 11-BETA-HSD1; CHOLESTEROL; MASS;

D O I：

10.2337/db08-1404

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：14 / 15

页数：2

共 12 条

[1] Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains [J].

Alberts, P ;

Nilsson, C ;

Selén, G ;

Engblom, LOM ;

Edling, NHM ;

Norling, S ;

Klingström, G ;

Larsson, C ;

Forsgren, M ;

Ashkzari, M ;

Nilsson, CE ;

Fiedler, M ;

Bergqvist, E ;

Öhman, B ;

Björkstrand, E ;

Abrahmsén, LB .

ENDOCRINOLOGY, 2003, 144 (11) :4755-4762

[2] Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice [J].

Alberts, P ;

Engblom, L ;

Edling, N ;

Forsgren, M ;

Klingström, G ;

Larsson, C ;

Rönquist-Nii, Y ;

Öhman, B ;

Abrahmsén, L .

DIABETOLOGIA, 2002, 45 (11) :1528-1532

[3] The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans [J].

Andrew, R ;

Westerbacka, J ;

Wahren, J ;

Yki-Järvinen, H ;

Walker, BR .

DIABETES, 2005, 54 (05) :1364-1370

[4] Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans [J].

Basu, Rita ;

Basu, Ananda ;

Grudzien, Meagan ;

Jung, Paul ;

Jacobson, Peer ;

Johnson, Michael ;

Singh, Ravinder ;

Sarr, Michael ;

Rizza, Robert A. .

DIABETES, 2009, 58 (01) :39-45

[5] Splanchnic cortisol production in dogs occurs primarily in the liver -: Evidence for substantial hepatic specific 11β hydroxysteroid dehydrogenase type 1 activity [J].

Basu, Rita ;

Edgerton, Dale S. ;

Singh, Ravinder J. ;

Cherrington, Alan ;

Rizza, Robert A. .

DIABETES, 2006, 55 (11) :3013-3019

[6] Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11β-hydroxysteroid dehydrogenase type 1 [J].

Berthiaume, Magalie ;

Laplante, Mathieu ;

Festuccia, William ;

Gelinas, Yves ;

Poulin, Sebastien ;

Lalonde, Josee ;

Joanisse, Denis R. ;

Thieringer, Rolf ;

Deshaies, Yves .

ENDOCRINOLOGY, 2007, 148 (05) :2391-2397

[7] DAILY CORTISOL PRODUCTION-RATE IN MAN DETERMINED BY STABLE ISOTOPE-DILUTION MASS-SPECTROMETRY [J].

ESTEBAN, NV ;

LOUGHLIN, T ;

YERGEY, AL ;

ZAWADZKI, JK ;

BOOTH, JD ;

WINTERER, JC ;

LORIAUX, DL .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (01) :39-45

[8] Cortisol effects on body mass, blood pressure, and cholesterol in the general population [J].

Fraser, R ;

Ingram, MC ;

Anderson, NH ;

Morrison, C ;

Davies, E ;

Connell, JMC .

HYPERTENSION, 1999, 33 (06) :1364-1368

[9]

Hawkins M, 2008, DIABETES, V57, pA99

[10] 11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice [J].

Hermanowski-Vosatka, A ;

Balkovec, JM ;

Cheng, K ;

Chen, HY ;

Hernandez, M ;

Koo, GC ;

Le Grand, CB ;

Li, ZH ;

Metzger, JM ;

Mundt, SS ;

Noonan, H ;

Nunes, CN ;

Olson, SH ;

Pikounis, B ;

Ren, N ;

Robertson, N ;

Schaeffer, JM ;

Shah, K ;

Springer, MS ;

Strack, AM ;

Strowski, M ;

Wu, K ;

Wu, TJ ;

Xiao, JY ;

Zhang, BB ;

Wright, SD ;

Thieringer, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (04) :517-527

← 1 2 →