Extramedullary Hematopoiesis in Myelodysplastic Syndromes: A Systematic Literature Review

被引:0
作者
Wang, Chen [1 ]
Shi, Yiyun [2 ]
机构
[1] Univ S Florida, Morsani Coll Med, Dept Internal Med, Tampa, FL 33620 USA
[2] Brown Univ, Dept Med, Warren Alpert Med Sch, Providence, RI 02912 USA
来源
HEMATO | 2022年 / 3卷 / 03期
关键词
extramedullary hematopoiesis; myelodysplastic syndromes; ring sideroblasts; CORD COMPRESSION; PATIENT; CLASSIFICATION; MIMICKING; PATHOLOGY;
D O I
10.3390/hemato3030039
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Extramedullary hematopoiesis is rarely seen in patients with myelodysplastic syndromes, and its clinical characterizations are not well-defined. Here, we systematically reviewed the published literature to summarize the clinical manifestations, treatments, and long-term outcomes of biopsy-proven extramedullary hematopoiesis in patients with myelodysplastic syndromes. We included 41 patients, and ring sideroblasts were the most common myelodysplastic subtype (30.6%). Extramedullary hematopoiesis was typically symptomatic on presentation due to local compression, frequently involving the liver or spleen (36.6%), or the paravertebral region (24.4%). Notably, ring sideroblasts were predominantly seen in patients with non-hepatosplenic involvement (38.5 vs. 6.7%, p = 0.034). Interventions, when required, usually included surgery (36.8%) or radiation (13.2%), which led to symptomatic improvement in 55.5% of patients. The median overall survival of the current cohort was 7 months. The current study confirms the rarity of extramedullary hematopoiesis as a complication of myelodysplastic syndromes; however, its outcomes in response to systemic modern therapies require further investigation.
引用
收藏
页码:569 / 573
页数:5
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