Critical role of the cholinergic system for object-in-place associative recognition memory

被引：46

作者：

Barker, Gareth R. I. ^{[1
]}

Warburton, Elizabeth C. ^{[1
]}

机构：

[1] Univ Bristol, Dept Anat, MRC Ctr Synapt Plast, Bristol BS8 1TD, Avon, England

来源：

LEARNING & MEMORY | 2009年 / 16卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

MEDIAL PREFRONTAL CORTEX; BASAL FOREBRAIN; VISUAL RECOGNITION; PERIRHINAL CORTEX; RHESUS-MONKEYS; UNILATERAL LESIONS; FORNIX TRANSECTION; WORKING-MEMORY; SCOPOLAMINE; RATS;

D O I：

10.1101/lm.1121309

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Object-in-place memory, which relies on the formation of associations between an object and the place in which it was encountered, depends upon a neural circuit comprising the perirhinal (PRH) and medial prefrontal (mPFC) cortices. This study examined the contribution of muscarinic cholinergic neurotransmission within this circuit to such object-in-place associative memory. Intracerebral administration of scopolamine in the PRH or mPFC impaired memory acquisition, but not retrieval and importantly we showed that unilateral blockade of muscarinic receptors simultaneously in both regions in opposite hemispheres, significantly impaired performance. Thus, object-in-place associative memory depends upon cholinergic modulation of neurones within the PRH-PFC circuit.

引用

页码：8 / 11

页数：4

共 29 条

[11] Crossed unilateral lesions of the medial forebrain bundle and either inferior temporal or frontal cortex impair object-reward association learning in Rhesus monkeys [J].

Easton, A ;

Gaffan, D .

NEUROPSYCHOLOGIA, 2001, 39 (01) :71-82

[12] A cholinergic explanation of dense amnesia [J].

Easton, A ;

Parker, A .

CORTEX, 2003, 39 (4-5) :813-826

[13] Unilateral lesions of the cholinergic basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys [J].

Easton, A ;

Ridley, RM ;

Baker, HF ;

Gaffan, D .

CEREBRAL CORTEX, 2002, 12 (07) :729-736

[14] Central cholinergic systems and cognition [J].

Everitt, BJ ;

Robbins, TW .

ANNUAL REVIEW OF PSYCHOLOGY, 1997, 48 :649-684

[15] Dissociating the role of the parietal cortex and dorsal hippocampus for spatial information processing [J].

Goodrich-Hunsaker, NJ ;

Hunsaker, MR ;

Kesner, RP .

BEHAVIORAL NEUROSCIENCE, 2005, 119 (05) :1307-1315

[16] Expression of long-term depression underlies visual recognition memory [J].

Griffiths, Sarah ;

Scott, Helen ;

Glover, Colin ;

Bienemann, Alison ;

Ghorbel, Mohamed T. ;

Uney, James ;

Brown, Malcolm W. ;

Warburton, E. Clea ;

Bashir, Zafar I. .

NEURON, 2008, 58 (02) :186-194

[17] Different hippocampal molecular requirements for short- and long-term retrieval of one-trial avoidance learning [J].

Izquierdo, LA ;

Barros, DM ;

Ardenghi, PG ;

Pereira, P ;

Rodrigues, C ;

Choi, H ;

Medina, JH ;

Izquierdo, I .

BEHAVIOURAL BRAIN RESEARCH, 2000, 111 (1-2) :93-98

[18] The role of the prefrontal cortex in object-place learning: a test of the attribute specificity model [J].

Kesner, RP ;

Ragozzino, ME .

BEHAVIOURAL BRAIN RESEARCH, 2003, 146 (1-2) :159-165

[19] AUTORADIOGRAPHIC ESTIMATION OF THE EXTENT OF REVERSIBLE INACTIVATION PRODUCED BY MICROINJECTION OF LIDOCAINE AND MUSCIMOL IN THE RAT [J].

MARTIN, JH .

NEUROSCIENCE LETTERS, 1991, 127 (02) :160-164

[20] Cholinergic-glutamatergic interactions in visual recognition memory of rhesus monkeys [J].

Matsuoka, N ;

Aigner, TG .

NEUROREPORT, 1996, 7 (02) :565-568

← 1 2 3 →