ATP-citrate lyase is essential for macrophage inflammatory response

被引：206
作者：
Infantino, Vittoria [1 ]
Iacobazzi, Vito [2 ,3 ]
Palmieri, Ferdinando [2 ,3 ]
Menga, Alessio [2 ]
机构：
[1] Univ Basilicata, Dept Sci, I-85100 Potenza, Italy
[2] Univ Bari, Dept Biosci Biotechnol & Pharmacol Sci, I-70125 Bari, Italy
[3] CNR, Inst Biomembranes & Bioenerget, I-70125 Bari, Italy
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2013年 / 440卷 / 01期
关键词：
ATP-citrate lyase; Nitric oxide; Reactive oxygen species; Prostaglandin E2; Inflammation; Immunometabolism; NF-KAPPA-B; CARRIER GENE; IDENTIFICATION; TRANSCRIPTION; METABOLISM; ACTIVATION; SECRETION; MECHANISM; INSULIN; SIGNALS;
D O I：
10.1016/j.bbrc.2013.09.037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Growing evidence suggests that energy metabolism and inflammation are closely linked and that cross-talk between these processes is fundamental to the pathogenesis of many human diseases. However, the molecular mechanisms underlying these observations are still poorly understood. Here we describe the key role of ATP-citrate lyase (ACLY) in inflammation. We find that ACLY mRNA and protein levels markedly and quickly increase in activated macrophages. Importantly, ACLY activity inhibition as well as ACLY gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators. In conclusion, we present a direct role for ACLY in macrophage inflammatory metabolism. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：105 / 111
页数：7
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