Stereoselective syntheses of beta-L-FD4C and beta-L-FddC

被引：16

作者：

Chen, SH

Li, XY

Li, J

Niu, CS

Carmichael, E

Doyle, TW

机构：

[1] Vion Pharmaceuticals, Inc., New Haven, CT 06511

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 11期

关键词：

D O I：

10.1021/jo970177k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereocontrolled syntheses of two potent antiviral agents, beta-L-FD4C and beta-L-FddC, were accomplished both in 10-step sequences, with an overall yield of 27% and 25%, respectively. It is worthwhile to mention that the introduction of a phenylseleno moiety to the C-2 alpha position of the lactone 4 can now be performed in a stereocontrolled fashion, providing the key intermediate 5 alpha in 75% yield.

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页码：3449 / 3452

页数：4

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