Inflammation in Huntington's disease: A few new twists on an old tale

被引：58

作者：

Costa Valadao, Priscila Aparecida ^{[1
]}

Santos, Kivia Barretos S. ^{[1
]}

Ferreira e Vieira, Talita Helen ^{[1
,2
]}

e Cordeiro, Thiago Macedo ^{[3
]}

Teixeira, Antonio Lucio ^{[4
,5
]}

Guatimosim, Cristina ^{[1
]}

de Miranda, Aline Silva ^{[1
,3
]}

机构：

[1] Univ Fed Minas Gerais, Dept Morfol, Belo Horizonte, MG, Brazil

[2] Fac Sete Lagoas, Dept Fisioterapia, Sete Lagoas, MG, Brazil

[3] Univ Fed Minas Gerais, Lab Interdisciplinar Invest Med, Fac Med, Belo Horizonte, MG, Brazil

[4] Santa Casa BH Ensino & Pesquisa, Belo Horizonte, MG, Brazil

[5] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, McGovern Med Sch, Neuropsychiat Program, Houston, TX 77030 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 348卷

关键词：

Huntington's disease; Huntingtin protein; Inflammation; Peripheral organs; MUTANT HUNTINGTIN; MICROGLIAL ACTIVATION; DIABETES-MELLITUS; OXIDATIVE STRESS; GROWTH-HORMONE; GENE; ABNORMALITIES; EXPRESSION; BIOMARKERS; REPEAT;

D O I：

10.1016/j.jneuroim.2020.577380

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Huntington's disease (HD) is a neurodegenerative disease characterized by prominent loss of neurons in the striatum and cortex. Traditionally research in HD has focused on brain changes as they cause progressive motor dysfunction, cognitive decline and psychiatric disorders. The discovery that huntingtin protein (HTT) and its mutated form (mHTT) are expressed not only in the brain but also in different organs and tissues paved the way for the hypothesis that HD might affect regions beyond the central nervous system (CNS). Besides pathological deposition of mHTT, other mechanisms, including inflammation, seem to underlie HD pathogenesis and progression. Altered inflammation can be evidenced even before the onset of classical symptoms of HD. Herein, we will discuss current pre-clinical and clinical evidence on immune/inflammatory changes in peripheral organs during HD development and progression. The understanding of the impact of inflammation on peripheral organs may open new venues for the development of novel therapeutic targets in HD.

引用

页数：11

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