A redox-activatable biopolymer-based micelle for sequentially enhanced mitochondria-targeted photodynamic therapy and hypoxia-dependent chemotherapy

被引：16

作者：

Li, Yanan ^{[1
]}

Sutrisno, Linawati ^{[2
]}

Hou, Yanhua ^{[3
]}

Fei, Yang ^{[1
]}

Xue, Chengcheng ^{[1
]}

Hu, Yan ^{[2
]}

Li, Menghuan ^{[1
]}

Luo, Zhong ^{[1
]}

机构：

[1] Chongqing Univ, Sch Life Sci, Chongqing 400044, Peoples R China

[2] Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Coll Bioengn, Chongqing 400044, Peoples R China

[3] Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Chongqing 401331, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 69期

基金：

中国国家自然科学基金;

关键词：

Tumors;

D O I：

10.1039/d0cc03667f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A tumor redox-activatable micellar nanoplatform based on the naturally occurring biomacromolecule hyaluronic acid (HA) was developed for complementary photodynamic/chemotherapy against CD44-positive tumors. Here HA was first conjugated withl-carnitine (Lc)-modified zinc phthalocyanine (ZnPc)viadisulfide linkage and then co-assembled with tirapazamine (TPZ) to afford the physiologically stable micellar nanostructure. The mitochondria-targeted photodynamic activity of ZnPc-Lc could efficiently activate the mitochondrial apoptosis cascade and deplete the oxygen in the tumor intracellular environment to amplify the hypoxia-dependent cytotoxic effect of TPZ.

引用

页码：9978 / 9981

页数：4

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