A clinical evaluation of the Janus Web Application, a software screening tool for drug-drug interactions

被引：12

作者：

Mannheimer, Buster ^{[1
]}

Ulfvarson, Johanna ^{[2
]}

Eklof, Sara ^{[3
]}

Bergqvist, Monica ^{[1
]}

von Bahr, Christer ^{[4
]}

机构：

[1] Soder Sjukhuset, Karolinska Inst, Dept Internal Med, SE-11883 Stockholm, Sweden

[2] Karolinska Inst, Dept Neurol Biol Care Sci & Soc, S-17176 Stockholm, Sweden

[3] Soder Sjukhuset, Dept Med, SE-11883 Stockholm, Sweden

[4] Soder Sjukhuset, Dept Med, Div Clin Pharmacol, SE-11883 Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 2008年 / 64卷 / 12期

关键词：

Drug interactions; Adverse drug reaction; Medical order entry systems; Software validation;

D O I：

10.1007/s00228-008-0547-x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIS). Methods One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interviewing the patient and looking into his/her medical records provided complementing information. A clinical pharmacologist judged which potential DDIs were clinically relevant. Potentially relevant DDIs identified by the JWA were then correlated with clinically relevant DDIs. Results A total of 150 significant potential DDIs were found. Sixteen percent (24/150) were judged to be clinically relevant. Conclusions A very small proportion of DDIs was considered clinically relevant in the specific clinical context. To optimise the software's user-friendliness, the following points need to be considered: the possibility of eliminating trivial potential DDIs, individualising drug alerts, and providing written information, accessible via a hyperlink.

引用

页码：1209 / 1214

页数：6

共 19 条

[1] Some unintended consequences of information technology in health care: The nature of patient care information system-related errors [J].

Ash, JS ;

Berg, M ;

Coiera, E .

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2004, 11 (02) :104-112

[2] Effect of computerized physician order entry and a team intervention on prevention of serious medication errors [J].

Bates, DW ;

Leape, LL ;

Cullen, DJ ;

Laird, N ;

Petersen, LA ;

Teich, JM ;

Burdick, E ;

Hickey, M ;

Kleefield, S ;

Shea, B ;

Vander Vliet, M ;

Seger, DL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (15) :1311-1316

[3] Computerized physician order entry: Helpful or harmful? [J].

Berger, RG ;

Kichak, JP .

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2004, 11 (02) :100-103

[4] PREDICTION OF CREATININE CLEARANCE FROM SERUM CREATININE [J].

COCKCROFT, DW ;

GAULT, MH .

NEPHRON, 1976, 16 (01) :31-41

[5] Janus computerised prescribing system provides pharmacological knowledge at point of care - design, development and proof of concept [J].

Eliasson, M ;

Bastholm, P ;

Forsberg, P ;

Henriksson, K ;

Jacobson, L ;

Nilsson, A ;

Gustafsson, LL .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 62 (04) :251-258

[6] The perils of CPOE [J].

Field, MH .

LANCET, 2004, 363 (9402) :86-86

[7] Improving recognition of drug interactions - Benefits and barriers to using automated drug alerts [J].

Glassman, PA ;

Simon, B ;

Belperio, P ;

Lanto, A .

MEDICAL CARE, 2002, 40 (12) :1161-1171

[8]

Hazlet T K, 2001, J Am Pharm Assoc (Wash), V41, P200

[9] Effects of computer-based clinical decision support systems on physician performance and patient outcomes - A systematic review [J].

Hunt, DL ;

Haynes, RB ;

Hanna, SE ;

Smith, K .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (15) :1339-1346

[10] EPIDEMIOLOGY OF DRUG-DRUG INTERACTIONS AS A CAUSE OF HOSPITAL ADMISSIONS [J].

JANKEL, CA ;

FITTERMAN, LK .

DRUG SAFETY, 1993, 9 (01) :51-59

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