Atrial Natriuretic Peptide, Arginine Vasopressin Peptide and Cortisol Serum Levels in Opiate-Dependent Patients

被引：13

作者：

Glahn, Alexander ^{[1
]}

Heberlein, Annemarie ^{[1
]}

Duersteler-MacFarland, Kenneth M. ^{[5
]}

Lenz, Bernd ^{[2
]}

Frieling, Helge ^{[1
]}

Groeschl, Michael ^{[3
]}

Wiesbeck, Gerhard A. ^{[5
]}

Kornhuber, Johannes ^{[2
]}

Boensch, Dominikus ^{[4
]}

Bleich, Stefan ^{[1
]}

Hillemacher, Thomas ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Ctr Addict Res CARe, DE-30625 Hannover, Germany

[2] Univ Hosp Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany

[3] Univ Hosp Erlangen, Dept Pediat, Erlangen, Germany

[4] Psychiat Hosp Rickling, Rickling, Germany

[5] Univ Basel, Hosp Psychiat, Div Subst Use Disorders, Basel, Switzerland

来源：

NEUROPSYCHOBIOLOGY | 2013年 / 67卷 / 02期

关键词：

Atrial natriuretic peptide; Arginine vasopressin peptide; Cortisol; Craving Opiate dependence; Opiate maintenance; Stress; PITUITARY-ADRENAL AXIS; HEROIN; PLASMA; ANXIETY; NEUROPEPTIDES; INVOLVEMENT; EXPRESSION; RECEPTOR; RELEASE; STRESS;

D O I：

10.1159/000346110

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Preclinical studies suggest that chronic drug abuse profoundly alters stress-responsive systems. The best studied of the stress-responsive systems in humans is the hypothalamic-pituitary-adrenal (HPA) axis. Apart from cortisol, arginine vasopressin peptide (AVP), and atrial natriuretic peptide (ANP) are known to directly impact upon the HPA axis in addictive behavior. We investigated alterations in ANP, AVP and cortisol serum levels in opiate-dependent patients who received diacetylmorphine treatment within a structured opiate maintenance program. ANP serum levels were significantly increased in opiate-dependent patients as compared to healthy controls, whereas AVP and cortisol serum levels were reduced. The ANP, AVP and cortisol serum levels were not significantly associated with the psychometric dimensions of heroin craving. In conclusion, chronic drug abuse profoundly alters stress-responsive systems like the HPA axis. Alterations of AVP, ANP and cortisol appear to constitute an important component in the neurobiology of opiate-dependent patients. Copyright (C) 2013 S. Karger AG, Basel

引用

页码：111 / 115

页数：5

共 24 条

[1] ATRIOPEPTIN - AN ENDOGENOUS CORTICOTROPIN-RELEASE INHIBITING HORMONE [J].

ANTONI, FA ;

HUNTER, EFM ;

LOWRY, PJ ;

NOBLE, JM ;

SECKL, JR .

ENDOCRINOLOGY, 1992, 130 (03) :1753-1755

[2] Persistent alterations of vasopressin and N-terminal proatrial natriuretic peptide plasma levels in long-term abstinent alcoholics [J].

Döring, WKH ;

Herzenstiel, MN ;

Krampe, H ;

Jahn, H ;

Pralle, L ;

Sieg, S ;

Wegerle, E ;

Poser, W ;

Ehrenreich, H .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2003, 27 (05) :849-861

[3] HYPOTHALAMUS-PITUITARY-ADRENAL AXIS OF HEROIN-ADDICTS [J].

FACCHINETTI, F ;

VOLPE, A ;

FARCI, G ;

PETRAGLIA, F ;

PORRO, CA ;

BARBIERI, G ;

CIONI, A ;

BALESTRIERI, A ;

GENAZZANI, AR .

DRUG AND ALCOHOL DEPENDENCE, 1985, 15 (04) :361-366

[4] Initial validation of two opiate craving questionnaires - The Obsessive Compulsive Drug Use Scale and the Desires for Drug Questionnaire [J].

Franken, IHA ;

Hendriks, VM ;

van den Brink, W .

ADDICTIVE BEHAVIORS, 2002, 27 (05) :675-685

[5] The Impact of Diacetylmorphine on Hypothalamic-Pituitary-Adrenal Axis Activity and Heroin Craving in Heroin Dependence [J].

Gerber, Hana ;

Borgwardt, Stefan J. ;

Schmid, Otto ;

Gerhard, Urs ;

Joechle, Wolfgang ;

Riecher-Roessler, Anita ;

Wiesbeck, Gerhard A. ;

Walter, Marc .

EUROPEAN ADDICTION RESEARCH, 2012, 18 (03) :116-123

[6] Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal [J].

Hillemacher, Thomas ;

Frieling, Helge ;

Luber, Katja ;

Yazici, Ayfer ;

Muschler, Marc A. N. ;

Lenz, Bernd ;

Wilhelm, Julia ;

Kornhuber, Johannes ;

Bleich, Stefan .

PSYCHONEUROENDOCRINOLOGY, 2009, 34 (04) :555-560

[7] COMPARISON OF PLASMA HORMONAL LEVELS BETWEEN HEROIN-ADDICTED AND NORMAL SUBJECTS [J].

HO, WKK ;

WEN, HL ;

FUNG, KP ;

NG, YH ;

AU, KK ;

MA, L .

CLINICA CHIMICA ACTA, 1977, 75 (03) :415-419

[8] Antidepressants and hypothalamic pituitary adrenocortical regulation [J].

Holsboer, F ;

Barden, N .

ENDOCRINE REVIEWS, 1996, 17 (02) :187-205

[9] Stress Hormone Regulation: Biological Role and Translation into Therapy [J].

Holsboer, Florian ;

Ising, Marcus .

ANNUAL REVIEW OF PSYCHOLOGY, 2010, 61 :81-109

[10] The Corticotropin-Releasing Hormone Network and the Hypothalamic-Pituitary-Adrenal Axis: Molecular and Cellular Mechanisms Involved [J].

Jose Bonfiglio, Juan ;

Inda, Carolina ;

Refojo, Damian ;

Holsboer, Florian ;

Arzt, Eduardo ;

Silberstein, Susana .

NEUROENDOCRINOLOGY, 2011, 94 (01) :12-20

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