The effects of antiepileptic drugs on cognitive functional magnetic resonance imaging

被引：23
作者：
Beltramini, Guilherme Coco [1 ]
Cendes, Fernando [1 ]
Yasuda, Clarissa Lin [1 ]
机构：
[1] Univ Estadual Campinas, Dept Neurol, Lab Neuroimaging, Campinas, SP, Brazil
来源：
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY | 2015年 / 5卷 / 02期
基金：
巴西圣保罗研究基金会;
关键词：
Antiepileptic drugs (AEDs); cognitive functional magnetic resonance imaging (fMRI);
D O I：
10.3978/j.issn.2223-4292.2015.01.04
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The cognitive dysfunction caused by antiepileptic drugs (AEDs) has been extensively described, although the mechanisms underlying such collateral effects are still poorly understood. The combination of functional magnetic resonance imaging (fMRI) studies with pharmacological intervention (pharmacoMRI or ph-MRI) offers the opportunity to investigate the effect of drugs such as AEDs on brain activity, including cognitive tasks. Here we review the studies that investigated the effects of AEDs [topiramate (TPM), lamotrigine (LMT), carbamazepine (CBZ), pregabalin (PGB), valproate (VPA) and levetiracetam (LEV)] on cognitive fMRI tasks. Despite the scarcity of fMRI studies focusing on the impact of AEDs on cognitive task, the results of recent work have provided important information about specific drug-related changes of brain function.
引用
收藏
页码：238 / 246
页数：9
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