Cucurbitane glycosides from Hemsleya panacis-scandens rhizomes

From the rhizomes of Hemsleya panacis-scandens, four new cucurbitane glycosides and a known glycoside, perseapicroside A, were isolated, The structures of these new glycosides, named scandenosides R8-R11, were determined as the 3-O-beta-D-glucopyranoside-26-O-beta-D-glucopy of 3 beta,26-dihydroxycucurbit-5-en-11-one, the 2-O-beta-D-glucopyranoside of 2 beta,3 alpha,16 alpha-trihydroxy-22,23,24,25,26,27-hexanorucurbit-5-ene-11,20-dione, the 3-O-beta-D-glucopyranoside of 2 beta,3 alpha,20(S),26,27-pentahydroxy-16 alpha,23(S)-epoxycucurbita-5,24-dien-11-one and the 3-O-beta-D-glucopyran oside-26-O-beta-gentiobioside of 3 beta,11 alpha,26-trihydroxy-5 beta,6 beta-epoxycucurbit-24-ene by spectroscopic and chemical methods. The structure of perseapicroside A was shown to be incorrect.