Sulfated fucan/fucosylated chondroitin sulfate-dominated polysaccharide fraction from low-edible-value sea cucumber ameliorates type 2 diabetes in rats: New prospects for sea cucumber polysaccharide based-hypoglycemic functional food

被引：54
作者：
Zhu, Qiyuan [1 ,2 ]
Lin, Lianzhu [1 ,2 ]
Zhao, Mouming [1 ,2 ]
机构：
[1] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510641, Peoples R China
[2] Guandong Food Green Proc & Nutr Regulat Technol R, Guangzhou 510641, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 159卷
关键词：
Thelenota ananas; Cucumaria frondosa; Sulfated fucan; Fucosylated chondroitin sulfate; Type; 2; diabetes; Hypoglycemic effect; ANTICOAGULANT ACTIVITIES; INSULIN-RESISTANCE; STRUCTURAL-CHARACTERIZATION; FUCOIDAN; MICROBIOTA; JAPONICUS; MELLITUS;
D O I：
10.1016/j.ijbiomac.2020.05.043
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sulfated fucan chondroitin sulfate-dominated polysaccharide fraction from low-edible-value sea cucumber may be a good alternative to high-edible-value sea cucumber-derived polysaccharide for application in hypoglycemic functional foods. To evaluate the potential effect of low-edible-value sea cucumber-derived polysaccharide frac-tion on type 2 diabetes (T2DM), two sulfated fucan/fucosylated chondroitin sulfate-dominated polysaccharide fractions screening from 10 global commercial low-edible-value sea cucumber species were investigated to iden-tify their anti-diabetics efficacies using a high-fat diet and streptozotocin-induced T2DM rat model. Sulfated fucan-dominated polysaccharide fraction from Thelenota ananas and fucosylated chondroitin sulfate -dominated polysaccharide fraction from Cucumaria frondosa ameliorated hyperglycemia, restored hypertriglyc-eridemia and hypercholesterolemia, decreased inflammatory status and oxidative stress, protected against liver injury, as well as improved insulin resistance and promoted accumulation of hepatic glycogen by activating IRS/PI3K/AKT signaling and regulating GSK-3 beta gene expression in T2DM rats. The current findings provide an available strategy for the commercialization of sea cucumber polysaccharide based-hypoglycemic functional food. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页码：34 / 45
页数：12
相关论文
共 48 条
[11]   Whole Grain Brown Rice Extrudate Ameliorates the Symptoms of Diabetes by Activating the IRS1/PI3K/AKT Insulin Pathway in db/db Mice [J].
Gao, Yue ;
Zhang, Mingwei ;
Zhang, Ruifen ;
You, Lijun ;
Li, Tong ;
Liu, Rui Hai .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 67 (42) :11657-11664
[12]   Proximate composition and nutritional quality of deep sea growth sea cucumbers (Stichopus japonicus) from different origins [J].
Gao, Yue ;
Li, Zhibo ;
Qi, Yanxia ;
Guo, Zhenyu ;
Lin, Yantong ;
Li, Wei ;
Hu, Yucai ;
Zhao, Qiancheng .
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2016, 96 (07) :2378-2383
[13]  
Hsieh CH, 2015, FOOD FUNCT, V6, P1887, DOI [10.1039/c5fo00124b, 10.1039/C5FO00124B]
[14]   Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs [J].
Hu, Rong ;
Wang, Ming-qing ;
Ni, Shi-hao ;
Wang, Ming ;
Liu, Ling-yu ;
You, Hai-yan ;
Wu, Xiao-hui ;
Wang, Yan-jing ;
Lu, Lu ;
Wei, Lian-bo .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 867
[15]   Fucoidan from sea cucumber protects against high-fat high-sucrose diet-induced hyperglycaemia and insulin resistance in mice [J].
Hu, Shiwei ;
Xia, Guanghua ;
Wang, Jingfeng ;
Wang, Yuming ;
Li, Zhaojie ;
Xue, Changhu .
JOURNAL OF FUNCTIONAL FOODS, 2014, 10 :128-138
[16]   Fucosylated Chondroitin Sulfate from Sea Cucumber Improves Insulin Sensitivity via Activation of PI3K/PKB Pathway [J].
Hu, Shiwei ;
Chang, Yaoguang ;
He, Min ;
Wang, Jingfeng ;
Wang, Yuming ;
Xue, Changhu .
JOURNAL OF FOOD SCIENCE, 2014, 79 (07) :H1424-H1429
[17]   Identification of a highly sulfated fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated tetrasaccharides units [J].
Hu, Yaqin ;
Li, Shan ;
Li, Junhui ;
Ye, Xingqian ;
Ding, Tian ;
Liu, Donghong ;
Chen, Jianchu ;
Ge, Zhiwei ;
Chen, Shiguo .
CARBOHYDRATE POLYMERS, 2015, 134 :808-816
[18]  
Jia R.B., 2019, INT J BIOL MAROMOL, DOI DOI 10.1016/J.JIJBIOMAC.2019.11.068
[19]  
Kale V., 2013, Bioactive Carbohydrates and Dietary Fibre, V2, P108
[20]   Pharmacological Potential of Sea Cucumbers [J].
Khotimchenko, Yuri .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (05)
12345