Sulfated fucan/fucosylated chondroitin sulfate-dominated polysaccharide fraction from low-edible-value sea cucumber ameliorates type 2 diabetes in rats: New prospects for sea cucumber polysaccharide based-hypoglycemic functional food

被引：54
作者：
Zhu, Qiyuan [1 ,2 ]
Lin, Lianzhu [1 ,2 ]
Zhao, Mouming [1 ,2 ]
机构：
[1] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510641, Peoples R China
[2] Guandong Food Green Proc & Nutr Regulat Technol R, Guangzhou 510641, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 159卷
关键词：
Thelenota ananas; Cucumaria frondosa; Sulfated fucan; Fucosylated chondroitin sulfate; Type; 2; diabetes; Hypoglycemic effect; ANTICOAGULANT ACTIVITIES; INSULIN-RESISTANCE; STRUCTURAL-CHARACTERIZATION; FUCOIDAN; MICROBIOTA; JAPONICUS; MELLITUS;
D O I：
10.1016/j.ijbiomac.2020.05.043
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sulfated fucan chondroitin sulfate-dominated polysaccharide fraction from low-edible-value sea cucumber may be a good alternative to high-edible-value sea cucumber-derived polysaccharide for application in hypoglycemic functional foods. To evaluate the potential effect of low-edible-value sea cucumber-derived polysaccharide frac-tion on type 2 diabetes (T2DM), two sulfated fucan/fucosylated chondroitin sulfate-dominated polysaccharide fractions screening from 10 global commercial low-edible-value sea cucumber species were investigated to iden-tify their anti-diabetics efficacies using a high-fat diet and streptozotocin-induced T2DM rat model. Sulfated fucan-dominated polysaccharide fraction from Thelenota ananas and fucosylated chondroitin sulfate -dominated polysaccharide fraction from Cucumaria frondosa ameliorated hyperglycemia, restored hypertriglyc-eridemia and hypercholesterolemia, decreased inflammatory status and oxidative stress, protected against liver injury, as well as improved insulin resistance and promoted accumulation of hepatic glycogen by activating IRS/PI3K/AKT signaling and regulating GSK-3 beta gene expression in T2DM rats. The current findings provide an available strategy for the commercialization of sea cucumber polysaccharide based-hypoglycemic functional food. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页码：34 / 45
页数：12
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