Rapid Synthesis of 1,3,4,4-Tetrasubstituted β-Lactams from Methyleneaziridines Using a Four-Component Reaction

被引：140

作者：

Cariou, Claire C. A. ^{[1
]}

Clarkson, Guy J. ^{[1
]}

Shipman, Michael ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/jo801664g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Graphics 2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted beta-lactams in moderate to good yields (46-63%) via a "one-pot" process that brings together four components with the formation of three new intermolecular carbon-carbon bonds.

引用

页码：9762 / 9764

页数：3

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