Association of TGF-β Canonical Signaling-Related Core Genes With Aortic Aneurysms and Aortic Dissections

被引：20

作者：

Chen, Jicheng

Chang, Rong

机构：

[1] Department of Vasculocardiology, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

关键词：

TGF-beta signaling; aortic aneurysm; aortic dissection; SMADs; smooth muscle cells; SMOOTH-MUSCLE-CELLS; LOEYS-DIETZ SYNDROME; MARFAN-SYNDROME; ARTERIAL ANEURYSMS; JUVENILE POLYPOSIS; SMAD4; MUTATION; RECEPTOR; ACTIVATION; LOSARTAN; DILATION;

D O I：

10.3389/fphar.2022.888563

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transforming growth factor-beta (TGF-beta) signaling is essential for the maintenance of the normal structure and function of the aorta. It includes SMAD-dependent canonical pathways and noncanonical signaling pathways. Accumulated genetic evidence has shown that TGF-beta canonical signaling-related genes have key roles in aortic aneurysms (AAs) and aortic dissections and many gene mutations have been identified in patients, such as those for transforming growth factor-beta receptor one TGFBR1 , TGFBR2, SMAD2, SMAD3, SMAD4, and SMAD6. Aortic specimens from patients with these mutations often show paradoxically enhanced TGF-beta signaling. Some hypotheses have been proposed and new AA models in mice have been constructed to reveal new mechanisms, but the role of TGF-beta signaling in AAs is controversial. In this review, we focus mainly on the role of canonical signaling-related core genes in diseases of the aorta, as well as recent advances in gene-mutation detection, animal models, and in vitro studies.

引用

页数：13

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