Finite element analysis of microneedle insertion into skin

被引：25

作者：

Chen, Shuhu ^{[1
]}

Li, Nannan ^{[1
]}

Chen, Jing ^{[1
]}

机构：

[1] Peking Univ, Natl Key Lab Micro Nano Fabricat Technol, Inst Microelect, Beijing 100871, Peoples R China

来源：

MICRO & NANO LETTERS | 2012年 / 7卷 / 12期

关键词：

TITANIUM MICRONEEDLES; MECHANICAL-BEHAVIOR; NEEDLE INSERTION; PREDICTION; SIMULATION; DELIVERY; FORCE;

D O I：

10.1049/mnl.2012.0585

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A report is presented on the modelling and verification of microneedle-skin interactions. A nonlinear finite element model based on the micro biomechanical properties of skin was established to simulate a microneedle being inserted into the skin. The deformation of skin and the force-displacement behaviour of the microneedle could be obtained. The accuracy was experimentally verified by measuring the relationship between force and displacements during insertion into mouse skin. With this model, the influences of different geometries on microneedle fracture were discussed, which was useful to optimise the microneedle design.

引用

页码：1206 / 1209

页数：4

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