One-pot three-component synthesis of functionalized spirooxindoles in gluconic acid aqueous solution

被引：70
|
作者：
Guo, Rui-Yun [1 ]
Wang, Ping [2 ]
Wang, Guo-Dong [1 ]
Mo, Li-Ping [1 ]
Zhang, Zhan-Hui [1 ]
机构：
[1] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Peoples R China
[2] Hebei Chem & Pharmaceut Vocat Technol Coll, Dept Chem & Environm Engn, Shijiazhuang 050026, Peoples R China
来源：
TETRAHEDRON | 2013年 / 69卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Spirooxindoles; Multicomponent reaction; One-pot; Gluconic acid aqueous solution; POLYETHYLENE-GLYCOL PEG-400; RECYCLABLE REACTION MEDIUM; MAGNETICALLY SEPARABLE CATALYST; CROSS-COUPLING REACTIONS; UREA-SALT MIXTURES; EFFICIENT SYNTHESIS; SOLVENT-FREE; MULTICOMPONENT REACTIONS; DERIVATIVES; SYSTEM;
D O I：
10.1016/j.tet.2012.12.081
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general, efficient, and green method for one-pot synthesis of functionalized spirooxindoles through three-component condensation reaction of isatins, cyclohexane-1,3-diones, and barbituric acids is described employing gluconic acid aqueous solution (GAAS) as a novel reaction medium and catalyst. The reaction medium could be recycled and reused several times without significant loss of its efficiency. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2056 / 2061
页数：6
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