A helix scaffold for the assembly of active protein kinases
被引:344
作者:
Kornev, Alexandr P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USAUniv Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA
Kornev, Alexandr P.
[1
]
Taylor, Susan S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USAUniv Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA
Taylor, Susan S.
[1
,2
]
Ten Eyck, Lynn F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Univ Calif San Diego, San Diego Supercomp Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA
Ten Eyck, Lynn F.
[2
,3
]
机构:
[1] Univ Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, San Diego Supercomp Ctr, La Jolla, CA 92093 USA
Structures of set of serine-threonine and tyrosine kinases were investigated by the recently developed bioinformatics tool Local Spatial Patterns (LSP) alignment. We report a set of conserved motifs comprised mostly of hydrophobic residues. These residues are scattered throughout the protein sequence and thus were not previously detected by traditional methods. These motifs traverse the conserved protein kinase core and play integrating and regulatory roles. They are anchored to the F-helix, which acts as an organizing "hub" providing precise positioning of the key catalytic and regulatory elements. Consideration of these discovered structures helps to explain previously inexplicable results.