The Sleep-Immunity Relationship

被引：118
作者：
Gamaldo, Charlene E. [1 ]
Shaikh, Annum K. [2 ]
McArthur, Justin C. [3 ]
机构：
[1] Johns Hopkins Sleep Disorders Ctr, Baltimore, MD 21287 USA
[2] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA
[3] Johns Hopkins Univ, Johns Hopkins Hosp, Sch Med, Dept Neurol, Baltimore, MD 21287 USA
来源：
NEUROLOGIC CLINICS | 2012年 / 30卷 / 04期
关键词：
Sleep; Inflammation; Insomnia; Infectious diseases; Apnea; Immunity; Interleukins; Cytokines; RESTLESS LEGS SYNDROME; CREUTZFELDT-JAKOB-DISEASE; FATAL FAMILIAL INSOMNIA; NECROSIS-FACTOR-ALPHA; HUMAN AFRICAN TRYPANOSOMIASIS; IRRITABLE-BOWEL-SYNDROME; C-REACTIVE PROTEIN; NIGHT-SHIFT WORK; MULTIPLE-SCLEROSIS; HIV-INFECTION;
D O I：
10.1016/j.ncl.2012.08.007
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Research models show a strong interrelationship between sleep quality and immune function. The proinflammatory cytokines, interleukin-1, interleukin-6, and tumor necrosis factor a are classified as official sleep-regulatory substances. However, sleep-promoting properties are also possessed by several other immune and proinflammatory cellular classes. This article reviews the current physiologic evidence for the prominent somnogenic and sleep-regulatory properties inherent to these immune substances. Clinical examples of this relationship are discussed from the perspective of infectious and primarily immune-related conditions associated with significant sleep disruption and from the perspective of immune dysregulation associated with several primary sleep disorders.
引用
收藏
页码：1313 / +
页数：33
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