Synthesis of Porous PEG Microgels Using CaCO3 Microspheres as Hard Templates

被引：46
|
作者：
Behra, Muriel [1 ]
Schmidt, Stephan [2 ]
Hartmann, Juergen [1 ]
Volodkin, Dmitry V. [2 ]
Hartmann, Laura [1 ]
机构：
[1] Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany
[2] Fraunhofer Inst Biomed Engn IBMT, D-14476 Potsdam, Germany
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2012年 / 33卷 / 12期
关键词：
calcium carbonate CaCO3; hard templating; poly(ethylene glycol) PEG hydrogels; porous microgels; CALCIUM-CARBONATE MICROPARTICLES; DRUG-DELIVERY APPLICATIONS; INDUCED PHASE-SEPARATION; POLYELECTROLYTE MICROCAPSULES; ENCAPSULATION; PARTICLES; POLYMERS; ADSORPTION; CAPSULES; FORM;
D O I：
10.1002/marc.201100863
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Porous poly(ethylene glycol) (PEG) microgels of both 17.6 and 8.3 mu m in diameter are synthesized via hard templating with calcium carbonate (CaCO3) microparticles. The synthesis is performed in three steps: loading of PEG macromonomers into CaCO3 microparticles, crosslinking via photopolymerization, and removal of the CaCO3 template under acidic conditions. The resulting porous PEG microgels are inverse replicates of their templates as indicated by light microscopy, cryo-scanning electron microscopy (cryo-SEM), and permeability studies. Thus this process allows for the straightforward and highly reproducible synthesis of porous hydrogel particles of two different diameters and porosities that show great potential as carriers for drugs or nanomaterials.
引用
收藏
页码：1049 / 1054
页数：6
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