The JAK/STAT pathway and Drosophila development

被引：51
作者：
Luo, H
Dearolf, CR
机构：
[1] Massachusetts Gen Hosp, Dept Pediat, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
[3] Texas A&M Univ, Coll Med, Syst Hlth Sci Ctr, Div Mol Cardiol,Cardiovasc Res Inst, Temple, TX 76508 USA
来源：
BIOESSAYS | 2001年 / 23卷 / 12期
关键词：
D O I：
10.1002/bies.10016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism to identify other interacting molecules and pathways. Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling. (C) 2001 John Wiley & Sons, Inc.
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收藏
页码：1138 / 1147
页数：10
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