Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring

被引：92

作者：

Iqbal, A. K. Mohammed ^{[1
]}

Khan, Ashraf Y. ^{[1
]}

Kalashetti, Mallikarjun B. ^{[1
]}

Belavagi, Ningaraddi S. ^{[1
]}

Gong, Young-Dae ^{[2
]}

Khazi, Imitiyaz Ahmed M. ^{[1
]}

机构：

[1] Karnatak Univ, Dept Chem, Dharwad 580003, Karnataka, India

[2] Dongguk Univ, Ctr Innovat Drug Lib Res, Coll Sci, Seoul, South Korea

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 53卷

关键词：

Thiazolidinediones; Pioglitazone analogs; Hypoglycemic activity; Hypolipidemic activity; PEROXISOME; ACTIVATION;

D O I：

10.1016/j.ejmech.2012.04.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel thiazolidinedione derivatives were synthesized by incorporating pharmacologically significant heterocycles viz, substituted thiazole, triazole, and oxadiazole moieties linked to the central phenyl ring via heteroatomlinkage with one/two carbon spacer as the structural analogs of Pioglitazone by employing multistep synthetic protocols. Structures of all the newly synthesized intermediates and target molecules were established by analytical and spectral data. These newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activities in male wistar rats. Some of the synthesized compounds demonstrated good activity. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：308 / 315

页数：8

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