Association Between p21 Ser31Arg Polymorphism and Gastrointestinal Tract Tumor Risk: A Meta-analysis

被引：2
作者：
Dong, Ying [1 ]
Wang, Xiaohua
Ye, Xiaofeng [2 ]
Wang, Guanhua [1 ,2 ]
Li, Yan [1 ,3 ]
Wang, Ningju [2 ]
Yang, Yinxue [4 ]
Chen, Zhiqiang [3 ]
Yang, Wenjun [1 ,2 ]
机构：
[1] Ningxia Med Univ, Key Lab Reprod & Hered Ningxia Reg, Yinchuan 750004, Ningxia, Peoples R China
[2] Ningxia Med Univ, Gen Hosp, Canc Hosp & Inst, Dept Oncol, Yinchuan 750004, Ningxia, Peoples R China
[3] Ningxia Med Univ, Gen Hosp, Dept Radiol, Yinchuan 750004, Ningxia, Peoples R China
[4] Ningxia Med Univ, Gen Hosp, Surg Lab, Ningxia 750004, Peoples R China
来源：
TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2015年 / 14卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Asian; Codon; 31; Gastrointestinal tract tumor; Meta analysis; p21;
D O I：
10.7785/tcrtexpress.2013.500422
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Human p21 gene is characterized by a polymorphism at codon 31 leading to a Serine-to- Arginine (S/R), two different alleles of p21 Ser31Arg (rs 1801270) polymorphism have been shown to differ significantly in their transcriptional efficiency. More and more investigations are now being carried out to examine a possible link between the p21 Ser31Arg polymorphism and cancer. However, the results were inconclusive. Therefore, we carried out a systematic review and meta-analysis to examine whether this polymorphism is associated with gastrointestinal tract tumor in Asian. Seven studies (n = 2690), comprising 967 cases and 1723 controls in Asian population, were included in our study. The meta-analysis showed significant association between Ser-allele or Ser/Ser genotype and the susceptibility to gastrointestinal tract tumor in overall studies (Ser-allele vs. Arg-allele: OR = 1.17, 95% CI: 1.04-1.31; Ser/Ser vs. Arg/Arg: OR = 1.38, 95% CI: 1.09-1.75; Ser/Ser vs. Arg/Ser: OR = 1.27, 95% CI: 1.05-1.53; Ser/Ser vs. Arg/Ser + Arg/Arg: OR = 1.29, 95% CI: 1.07-1.54). Despite the limitations, the results of the present meta-analysis suggested that, in the p21 Ser31Arg polymorphism, Ser-allele and Ser/Ser genotype might be risk factors for gastrointestinal tract tumor in Asian populations.
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收藏
页码：627 / 633
页数：7
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