LACK OF HYDROXYLATED FULLERENE TOXICITY AFTER INTRAVENOUS ADMINISTRATION TO FEMALE SPRAGUE-DAWLEY RATS

被引：13

作者：

Monteiro-Riviere, Nancy A. ^{[1
]}

Linder, Keith E. ^{[1
]}

Inman, Alfred O. ^{[1
]}

Saathoff, John G. ^{[1
]}

Xia, Xin-Rui ^{[1
]}

Riviere, Jim E. ^{[1
]}

机构：

[1] N Carolina State Univ, Ctr Chem Toxicol Res & Pharmacokinet, Raleigh, NC 27607 USA

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES | 2012年 / 75卷 / 07期

基金：

美国国家卫生研究院;

关键词：

PHARMACOKINETICS; SKIN;

D O I：

10.1080/15287394.2012.670894

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Hydroxylated fullerenes (C60OHx) or fullerols are water-soluble carbon nanoparticles that have been explored for potential therapeutic applications. This study assesses acute in vivo tolerance in 8-wk-old female Sprague-Dawley rats to intravenous (iv) administration of 10 mg/kg of well-characterized C-60(OH)(30). Complete histopathology and clinical chemistries are assessed at 8, 24, and 48 h after dosing. Minor histopathology changes are seen, primarily in one animal. No clinically significant chemistry changes were observed after treatment. These experiments suggest that this fullerol was well tolerated after iv administration to rats.

引用

页码：367 / 373

页数：7

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